The radiological versatility of fibrous dysplasia: An 8-year retrospective radiographic analysis in a north Indian population

Abstract

Objective:The aim of this study was to examine the clinical and radiographic presentation of fibrous dysplasia through an 8-year retrospective study in patients who reported to the outpatient unit of the Kothiwal Dental College and Research Centre, Moradabad.Materials and Methods:The clinical file records and radiographs of the patients who reported to the outpatient clinic in the Department of Oral Medicine and Radiology were retrospectively reviewed for histopathologically diagnosed fibrous dysplasia. A detailed analysis of the clinical and radiographic features of the 14 cases retrieved was carried out.Results:Almost all the patients presented with a complaint of swelling on the side of the face. The maxilla was more frequently involved than the mandible. The most common radiographic pattern observed was the ground-glass appearance, followed by orange peel, cotton wool, sunray and thumb print appearance, which leads to a perplex differential diagnosis.Conclusion:Awareness of the versatile features of fibrous dysplasia evident through this study is essential in the accurate diagnosis and proper treatment planning of such lesions.

Fibrous dysplasia of the maxillofacial area: a 15-year retrospective study

“…Хотя рентгенологические признаки ФД весьма специфичны: истончение кортикального слоя с четкими краями и вид мозгового слоя по типу «матового стекла» [29], существует достаточно большая группа фиброзно-костных поражений, характери зующихся сочетанием трабекулярных и плотных участков в очаге [9,19,20]. Многие авторы отмечают значительную вариабельность сочетания этих компонентов при ФД, что затрудняет дифференциальную диагностику [10,19,20,28,30,31]. На ранней стадии ФД рентгенологический очаг более прозрачный с хорошо очерченными краями и литическим центром [20,26,28,31,32].…”

Computed Tomography in Craniofacial Fibrous Dysplasia: A Case Series with Review of Literature and Classification Update

“…It was originally described by Lichtenstein more than sixty years ago [ 1 , 16 ]. It presents with replacement of the osseous structures with cellular fibrous tissue containing foci of ossification [ 1 - 4 , 17 - 20 ]. Researchers have revealed its association with mutation in the gene (GNAS I) [ 21 - 24 ] which results in the encoding of the subunit of stimulatory G-protein (Gs) [ 21 - 24 ].…”

“…This will eventually results in the proliferation and differentiation of preosteoblasts due to increased production of cyclic adenosine monophosphate (cAMP) [ 2 , 4 - 9 , 21 - 24 ]. It is evident from the literature that most frequently (in almost 80% of the cases) FD affects only one bone [ 17 - 20 ] and this form is called monostotic FD while in case multiple bones are involved, it is called as polyostotic FD [ 2 , 10 , 11 ]. The polyostotic form can also present features like café-au-lait skin pigmentation and precocious puberty in McCune-Albright syndrome, which affects mainly young females [ 4 , 9 , 17 - 20 ].…”

“…It is evident from the literature that most frequently (in almost 80% of the cases) FD affects only one bone [ 17 - 20 ] and this form is called monostotic FD while in case multiple bones are involved, it is called as polyostotic FD [ 2 , 10 , 11 ]. The polyostotic form can also present features like café-au-lait skin pigmentation and precocious puberty in McCune-Albright syndrome, which affects mainly young females [ 4 , 9 , 17 - 20 ]. When the sphenoid, zygomatic, frontonasal bones and the base of the skull are affected, the disease is called craniofacial FD [ 12 , 13 , 17 - 20 ].…”

“…The polyostotic form can also present features like café-au-lait skin pigmentation and precocious puberty in McCune-Albright syndrome, which affects mainly young females [ 4 , 9 , 17 - 20 ]. When the sphenoid, zygomatic, frontonasal bones and the base of the skull are affected, the disease is called craniofacial FD [ 12 , 13 , 17 - 20 ]. Craniofacial involvement in FD is seen in both monostotic and polyostotic forms [ 9 , 10 ].…”