The radiolysis of aqueous solutions of cysteine in the presence of oxygen

Al-Thannon, Adnan; Barton, John P.; Packer, John E.; Sims, Ritchie John; Trumbore, Conrad N.; Winchester, R. V.

doi:10.1016/0020-7055(74)90024-2

Cited by 56 publications

(25 citation statements)

References 20 publications

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“…A marked increase in the values of G(-RSH), G(RSSR), G(H 2 0 2 ) is observed with increasing pH above pH ~ 5 (Barton and Packer, 1970;Al-Thannon et al, 1974). The evidence is that the thiolate ion competes with oxygen (reaction 64) for thiyl radicals via…”

Section: Oxygenated Solutions 23mentioning

confidence: 93%

Reaction mechanisms in the radiolysis of peptides, polypeptides and proteins

Garrison¹

1985

105

162

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Section: Oxygenated Solutions 23mentioning

confidence: 93%

Reaction mechanisms in the radiolysis of peptides, polypeptides and proteins

Garrison¹

1985

105

162

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“…Cells are rich in reductants which can react directly with dioxygen, albeit at moderate rates, and oxygen reduction which occurs without the benefit of enzymatic mediation is most likely to proceed by the univalent route. Among the compounds of biological relevance which are known to autoxidize in vitro and in so doing to produce O2 are hydroquinones (8), leukoflavins (8,9), catecholamines (10,11), thiols (12)(13)(14)(15), tetrahydopterins (16)(17)(18)(19), reduced ferredoxins (20)(21)(22)(23)(24)(25), ferrocytochrome c (26,27), ferrocytochrome b s (28), hemoglobins (29)(30)(31)(32)(33), and myoglobin (34). There are enzymes that catalyze the univalent reduction of dioxygen.…”

Section: Some Biological Sources Of Superoxidementioning

confidence: 99%

Superoxide Radical and Superoxide Dismutases

Fridovich¹

1981

Topics in Environmental Physiology and Medicine

331

337

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The metalloenzymes that have been named superoxide dismutases have several attributes. They are abundant, widely distributed, essential as a defense against oxygen toxicity; they are also unique among enzymes in that their natural substrate is an unstable free radical. They are evolution's answer to the biological production of the superoxide radical (0 2 ), This free radical, previously considered only in connection with the high energy irradiation of oxygenated aqueous media, is also produced under ordinary circumstances within respiring cells. The superoxide radical is intrinsically reactive and can furthermore engender other enormously reactive radicals and excited states which are potentially capable of destroying the delicate chemical architecture of the cell. The intermediates of oxygen reduction, i.e., O 2 , H 2 0 2 , and OH', are the primary cause of oxygen toxicity; the enzymes, which catalytically scavenge them or prevent their production, are the foremost defenses which limit that toxicity. H2~ and the catalases anc! peroxidases, which scavenge it, are discussed in other chapters of this volume. We shall devote ourselves to superoxide and the superoxide dismutases.

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“…This note supplements our preliminary reports on the radiochemical yield G(-GSH) in O2 containing solutions of pH 7, and on some pulse-radiolysis experiments (Quintiliani, Esfandi, Matsui andGorin 1973, Quintiliani, Badiello, Tamba andGorin 1976), and it complements the reports of other investigators (Lal, Armstrong andWieser 1969, Owen andWilbraham 1972), especially the recent paper by Lal (1976) which gives an analysis of the radiolysis products . Also pertinent are the numerous investigations of the radiolysis of cysteine, which have recently been reviewed, together with new experimental results, by Al-Thannon, Barton, Packer, Sims, Trumbore and Winchester (1974) .…”

Section: Introductionmentioning

confidence: 99%