The Radioprotective Effects of Combined Hypoxia and AET in Mice

Zatz, Leslie M.

doi:10.1080/09553006314550101

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…No time points were analyzed beyond 30 days post-radiation; indeed, although radiation-induced late effects had been recognized by this time, including carcinogenesis, developmental disturbances, and radiation cataracts, none of these endpoints were the subject of interest in the surveyed articles. A degree of mechanistic evaluation was attempted in a number of the studies, with investigators examining oxygen tension in various organs post-radiation and comparing aerobic versus hypoxic/anoxic conditions (van der Meer & van Bekkum 1959;Grant & Vos 1962;Vos & Kaalen 1962;Vergroesen et al 1963); interestingly, some investigators used hypothermia as an induction mechanism for the hypoxia in in vivo models (Weiss 1961;Vergroesen et al 1963;Zatz 1963), ignoring the potential for any radiation protective features of the hypothermia itself (Cheng et al 2015).…”

Section: Kickmentioning

confidence: 99%

Saving normal tissues – a goal for the ages

Groves

Williams

2019

International Journal of Radiation Biology

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Purpose: Almost since the earliest utilization of ionizing radiation, many within the radiation community have worked towards either preventing (i.e. protecting) normal tissues from unwanted radiation injury or rescuing them from the downstream consequences of exposure. However, despite over a century of such investigations, only incremental gains have been made towards this goal and, with certainty, no outright panacea having been found. In celebration of the 60 th anniversary of the International Journal of Radiation Biology and to chronicle the efforts that have been made to date, we undertook a non-rigorous survey of the articles published by normal tissue researchers in this area, using those that have appeared in the aforementioned journal as a road map. Three 'snapshots' of publications on normal tissue countermeasures were taken: the earliest (1959-1963) and most recent (2013-2018) 5-years of issues, as well as a 5-year intermediate span (1987-1991). Conclusions: Limiting the survey solely to articles appearing within International Journal of Radiation Biology likely reduced the number of translational studies interrogated given the basic science tenor of this particular publication. In addition, by taking 'snapshots' rather than considering the entire breadth of the journal's history in this field, important papers that were published during the interim periods were omitted, for which we apologize. Nonetheless, since the journal's inception, we observed that, during the chosen periods, the majority of studies undertaken in the field of normal tissue countermeasures, whether investigating radiation protectants, mitigators or treatments, have focused on agents that interfere with the physical, chemical and/or biological effects known to occur during the acute period following whole body/ high single dose exposures. This relatively narrow approach to the reduction of normal tissue effects, especially those that can take months, if not years, to develop, seems to contradict our growing understanding of the progressive complexities of the microenvironmental disruption that follows the initial radiation injury. Given the analytical tools now at our disposal and the enormous benefits that may be reaped in terms of improving patient outcomes, as well as the potential for

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