The Radioprotective Effects of Curcumin and Trehalose Against Genetic Damage Caused By I-131

Abstract

Background:Thyroid cancer has been growing rapidly during the last decades. Radioiodine-131 (I-131) as an appropriate therapy modality is currently using in the treatment of cancer and hyperthyroidism diseases. This radiotracer is considered as a cause of oxidative DNA damage in nontarget cells and tissues. The aim of this study was to investigate the effects of curcumin and trehalose on the level of DNA double-strand breaks (DSBs) caused by I-131 in human lymphocytes.Materials and Methods:First, 6-mL blood samples were taken from each of the five volunteers. After 1 h of preincubation with the antioxidants, a total of 20 μCi I-131/2 mL (blood + NaCl) was added to each sample, and then, the samples were reincubated for 1 h. Lymphocytes were separated and the mean DSB levels were measured for each sample through γ-H2AX assay to evaluate the effects of antioxidants.Results:After 1-h incubation with I-131, the DSBs increased by 102.9% compared to the control group (0.343 vs. 0.169 DSB/cell; P = 0.00). Furthermore, compared to the control + I-131 group, curcumin and trehalose reduced the DSBs by 42% and 38%, respectively. There was a significant decrement (P = 0.00) in the levels of DSBs of the curcumin + I-131 and trehalose + I-131 subgroups compared to the control + I-131 subgroup. Furthermore, there was no significant relationship between the radioprotective effect of curcumin and trehalose (P = 0.95).Conclusion:The use of curcumin and trehalose as antioxidant can reduce the numbers of DSBs caused by I-131. Meanwhile, the radioprotective effect of curcumin was more than trehalose.

The role of non-coding RNAs in chemotherapy for gastrointestinal cancers

“… 4 , 5 , 6 , 7 Recent studies have identified a new type of ncRNA, termed circular RNA (circRNA). 8 , 9 , 10 Many circRNAs have been shown to be produced from the exons of coding genes, and several of them do not translate to proteins. 8 , 10 , 11 Figure 1 summarizes the biogenesis of various ncRNAs, including miRNAs, 5 , 12 , 13 siRNAs, lncRNAs, 4 and circRNAs.…”

The Radioprotective Effects of Melatonin and Nanoselenium on DNA Double-Strand Breaks in Peripheral Lymphocytes Caused by I-131

“…Radioprotector agents can be used to prevent or reduce DNA DSBs in peripheral lymphocytes induced by radiation. [ 18 19 20 21 22 ] For instance, it has reported that melatonin can enhance DNA repair induced by ionizing radiation, chemotherapeutic drugs, and some other mutagens which this property of melatonin is directly related to its interaction with enzymes involved in DNA repair. [ 23 24 25 26 ] In this regard, for example, this radioprotector through direct phosphorylation of Ser15 in p53 inhibits cell proliferation, providing more time for repairing the damaged DNA; hence, the accumulated DNA damage is avoided as well as cell death or probability of genomic instability is reduced.…”

Erratum: The radioprotective effects of curcumin and trehalose against genetic damage caused by I-131

“…In the article titled “The Radioprotective Effects of Curcumin and Trehalose Against Genetic Damage Caused By I-131”, published on pages 99-104, Issue 2, Volume 33 of Indian Journal of Nuclear Medicine[ 1 ], the name of the sixth author is written incorrectly as “Bagher Fahood” instead of “Bagher Farhood”.…”