The Radioprotective Effects of Vasopressin on the Gastrointestinal Tract of Mice

Abstract

Three-hundred Balb/C mice were used to assess the effect of vasopressin on the response of the gastrointestinal tract to irradiation. Median lethal doses were determined for control and vasopressin treated animals in which the whole abdomen was irradiated. There was a significant difference in LD50/6 (882 +/- 27 for controls vs. 1051 +/- 23 for vasopressin-treated animals). In addition studies demonstrated a significant difference in the survival rate of jejunal crypts at 800 and 1,000 rads.

Low-Intensity Exercise Modulates Gut Microbiota to Fight Against Radiation-Induced Gut Toxicity in Mouse Models

“…Radiotherapy as a milestone for oncotherapy is applied to more than 50% of the global cancer patients, but the radiation toxicity of the whole body, especially for adjacent organs, is urgently worrisome ( Citrin, 2017 ; De Ruysscher et al, 2019 ). For example, abdomen local irradiation, as a common means for treating abdominopelvic tumor, always leads harm to the hematopoietic system, GI tract, and even reproductive system, which is near the exposed area ( Rappleye et al, 1975 ; Zhang et al, 2016 ; Oktem et al, 2018 ). As an organ within the treatment field for all intra-abdominal, retroperitoneal, and pelvic tumors, the intestine gets interfered unavoidably during or after radiotherapy, manifesting in acute (or chronic) inflammation, apoptosis, and fibrosis ( Wei et al, 2016 ).…”