The range of normal values of liver enzymes in the era of metabolic syndrome: the need for a redefinition

Wingeyer, Silvia D. Perés; Larrañaga, Gabriela de; Belli, Susana; Graffigna, Mabel; Fainboim, Hugo

doi:10.1097/meg.0b013e3282fe6e99

Cited by 3 publications

(2 citation statements)

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“…The results of this study could better improve the historical data to determine the relationship between liver enzymes and MetS development, and provide a more robust evidence to support the clinical diagnosis of the metabolic syndrome. Further, some studies [ 36 , 38 , 41 ] indicated that ALT level within the normal range was associated with the metabolic syndrome and its components. This indicated that in clinical diagnosis, the level of liver enzymes might change without departing from the normal range, but may indicate early metabolic disorder occurs.…”

Section: Discussionmentioning

confidence: 99%

Liver enzymes and metabolic syndrome: a large-scale case-control study

Zhang

Jiang

et al. 2015

Oncotarget

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Previous studies suggested that elevated liver enzymes could be used as potential novel biomarkers of Metabolic syndrome (MetS) and its clinical outcomes, although the results were inconsistent and the conclusions were underpowered. A case-control study with 6,268 MetS subjects and 6,330 frequency-matched healthy controls was conducted to systematically evaluated levels of four liver enzymes (ALT, AST, GGT and ALP), both in overall populations and in subjects with normal liver enzymes, with MetS risk using both quartiles and continuous unit of liver enzymes. We found significant associations were detected for all above analyses. Compared with quartile 1 (Q1), other quartiles have significant higher MetS risk, with ORs ranging from 1.15 to 18.15. The highest effected was detected for GGT, for which the OR value for the highest versus lowest quartile was 18.15 (95% CI: 15.7-20.9). Mutual adjustment proved the independence of the relations for all four liver enzymes. Sensitivity analyses didn't materially changed the trend. To the best of our knowledge, this study should be the largest, which aimed at evaluating the association between liver enzymes measures and MetS risk. The results can better support that liver enzyme levels could be used as clinical predictors of MetS.

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Section: Discussionmentioning

confidence: 99%

Liver enzymes and metabolic syndrome: a large-scale case-control study

Zhang

Jiang

et al. 2015

Oncotarget

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“…The consumption of a fructose-rich diet has been associated with elevated activity of ALT, a liver enzyme that serves as a marker of liver damage, therefore its serum concentration can be used to assess hepatotoxicity (Liu et al 2014;Aulbach and Amuzie 2017). Studies have found that although serum ALT concentrations can indicate liver disease, they do not always indicate the presence of significant liver disease or other MetS components in rodents (Perés Wingeyer et al 2008;Kang et al 2011). In the current study, serum ALT levels remained normal, this may be due to the lack of severe liver damage.…”

Section: Discussionmentioning

confidence: 99%

Effect of quercetin administration during the first two weeks post-weaning on the development of non-alcoholic fatty liver disease and dyslipidaemia in Sprague Dawley rats fed a high fructose diet

Tladi,

Erlwanger,

Donaldson

2024

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Hepatic steatosis and dyslipidaemia are associated with excessive fructose consumption. We investigated the effect of quercetin intake during the early pre-weaning period on metabolic dysfunction caused by a high fructose diet. Sprague Dawley rats, 21-day-old, were weaned onto standard rat chow and randomly allocated to four groups which either water or 20% fructose solution to drink with or without quercetin (100 mg/kg body mass). Quercetin was administered for two weeks. Thereafter, rats continued on their respective diets for six weeks without quercetin. Terminally, serum triglyceride concentrations were not significantly different (p > 0.05) between males across groups. However, females receiving quercetin alone had lower serum triglyceride levels than those receiving fructose (p < 0.01). Quercetin increased the incidence of hepatic steatosis in female rats. Quercetin intake in the immediate post-weaning period may prevent hypertriglyceridemia. However, female rats receiving quercetin alone are predisposed to hepatic steatosis associated with a high fructose diet.

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