The Range of Protons in Human Skullbone

Koehler, Andreas; Dickinson, Jill; Preston, William

doi:10.2307/3571939

Cited by 15 publications

(9 citation statements)

References 4 publications

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“…Our results compare quite well with the experimental mean excitation energy reported by Hiraoka et al [28] for "hard bone" substitute (density = 1.826 g/cm 3 ), which is 114.0 eV. Moreover, an experimental mass stopping power ratio for 100 MeV protons in skull bone (with composition and density very similar to cortical bone) with respect to liquid water was reported to be 0.900 ± 0.005 [27]; at this energy our results yield a ratio of 0.894, which is in very good agreement with the experiment data. Therefore, an important outcome of the work reported in this paper for the stopping of H and He beams in HAp is the successful application to the calculation of the energy loss of charged particles in human cortical bone, whose presence intercepting the ion-beam path in cancer treatment planning must be properly taken into account.…”

Section: Applications To Cortical Bonesupporting

confidence: 91%

“…The I value obtained for cortical bone (113.9-115.0 eV) satisfactorily agrees with the experimental value (114.0 eV) for "hard bone" substitute [28], and yields a bone-water mass stopping power ratio for 100 MeV protons of 0.894, which is in excellent agreement with the experimental value of 0.900 ± 0.005 reported for skullbone [27].…”

Section: Summary and Implicationssupporting

confidence: 88%

“…So far the main source of stopping power for ion beams in bone is the additivity of atomic stopping powers [25,26], since experimental data are very scarce [27,28]. Moreover, bone being a natural composite of collagen protein and mineral hydroxyapatite [29], no experimental data exist for the stopping power of its main constituent, which is calcium hydroxyapatite (HAp), with stoichiometric formula Ca 10 (PO 4 ) 6 (OH) 2 [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

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Energy deposition of H and He ion beams in hydroxyapatite films: A study with implications for ion-beam cancer therapy

et al. 2014

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Ion-beam cancer therapy is a promising technique to treat deep-seated tumors; however, for an accurate treatment planning, the energy deposition by the ions must be well known both in soft and hard human tissues. Although the energy loss of ions in water and other organic and biological materials is fairly well known, scarce information is available for the hard tissues (i.e., bone), for which the current stopping power information relies on the application of simple additivity rules to atomic data. Especially, more knowledge is needed for the main constituent of human bone, calcium hydroxyapatite (HAp), which constitutes 58% of its mass composition. In this work the energy loss of H and He ion beams in HAp films has been obtained experimentally. The experiments have been performed using the Rutherford backscattering technique in an energy range of 450-2000 keV for H and 400-5000 keV for He ions. These measurements are used as a benchmark for theoretical calculations (stopping power and mean excitation energy) based on the dielectric formalism together with the MELF-GOS (Mermin energy loss function-generalized oscillator strength) method to describe the electronic excitation spectrum of HAp. The stopping power calculations are in good agreement with the experiments. Even though these experimental data are obtained for low projectile energies compared with the ones used in hadron therapy, they validate the mean excitation energy obtained theoretically, which is the fundamental quantity to accurately assess energy deposition and depth-dose curves of ion beams at clinically relevant high energies. The effect of the mean excitation energy choice on the depth-dose profile is discussed on the basis of detailed simulations. Finally, implications of the present work on the energy loss of charged particles in human cortical bone are remarked.

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Section: Applications To Cortical Bonesupporting

confidence: 91%

Section: Summary and Implicationssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Energy deposition of H and He ion beams in hydroxyapatite films: A study with implications for ion-beam cancer therapy

et al. 2014

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“…In other words, because 'of variation of density and composition of tissue, bone, sinuses~ etc., it is difficult to predict exactly at what depth the Bragg peak will occur. Koehler, Dickinson, and Preston (1965) give a different solution to the problem.…”

Section: Possible Applicationsmentioning

confidence: 99%

Tissue activation studies with alpha-particle beams

Maccabee¹,

Madhvanath²,

Raju³

1969

pmb

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The positron-emitting activation of tissue by a-particle beams has been studied, using the annihilation y-ray coincidence detection technique, and the Anger positron camera.The decay spectrum in tissue following irradiation by 53 Mev a-particles from the Berkeley 88-inch cyclotron has been measured, as well a3 a visualization of the activation pattern resulting from a 910 Mev a-particle beam stopping in a tissue-like plastic phantom, a t the Berkeley 184-inch synchrocyclotron. Also studied were the activation patterns resulting from transmission of 910 MeV a-beams through a wax heed phantom, end the activation pattern in patients' heads resulting from one sitting for the pituitary ablation therapy technique. With alight improvements in resolution and sensitivity, en " on-line " positron camera technique could be useful for alignment of the end of the beam track in &eggpeak therapy with heavy charged particles. There are other novel applications which might be possible, using tissue activation techniques.

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“…The advantage of using diodes lies in their small size and low cost. Commercially available miniature silicon diodes have been investigated by Koehler (1965). We have studied miniature silicon diodes to appraise their usefulness at the biomedical facilities of the cyclotrons at the Lawrence Radiation Laboratory.…”

Section: Introductionmentioning

confidence: 99%