The range of subtle rise in serum progesterone levels following controlled ovarian hyperstimulation associated with lower in vitro fertilization pregnancy rates is determined by the source of manufacturer

Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression

“…However, the threshold of progesterone on the day of HCG administration, used to classify patients with or without premature progesterone rise, varies considerably in the literature. Several values have been proposed, such as 0.9 ng/ml (Edelstein et al, 1990;Fanchin et al, 1993;Hofmann et al, 1996;Martinez et al, 2004;Miller et al, 1996;Moffitt et al, 1997;Schoolcraft et al, 1991;Silverberg et al, 1991;Ubaldi et al, 1996b;Urman et al, 1999), 1.0 ng/ml (Check et al, 1993(Check et al, , 1994Shechter et al, 1994) or 1.2 ng/ml (Bosch et al, 2003).…”

Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate

“…Although serum progesterone concentration in the late follicular phase is considerably lower than that observed in connection with the mid-cycle surge of gonadotrophins or as induced by human chorionic gonadotrophin (HCG) for ovulation induction, even subtle increases in relatively low progesterone concentrations have been suspected to negatively affect ongoing pregnancy rates in connection with ovarian stimulation, possibly through an advancement of endometrial maturation (Fanchin et al, 1997a;Smitz et al, 2007). A number of studies have reported a negative association between progesterone concentration and clinical pregnancy rate (Azem et al, 2008;Bosch et al, 2003Bosch et al, , 2010Check et al, 1993;Fanchin et al, 1993Fanchin et al, , 1997bHarada et al, 1996;Shulman et al, 1996), while many others found no association (Abuzeid and Sasy, 1996;Bustillo et al, 1995;Check, 1994;Doldi et al, 1999;Edelstein et al, 1990;Givens et al, 1994;Hofmann et al, 1993;Levy et al, 1995;Martinez et al, 2004;Miller et al, 1996;Moffitt et al, 1997;Niu et al, 2008;Silverberg et al, 1991;Ubaldi et al, 1995;Urman et al, 1999;Venetis et al, 2007). Collectively, in 2007 a meta-analysis concluded that there was no statistical association between the late-follicular-phase progesterone concentrations and the ongoing pregnancy rates (Venetis et al, 2007).…”

Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers

“…A large number of clinical studies examined the effect of a subtle rise in serum P levels on the day of hCG administration in GnRH agonist cycles on pregnancy rates, but results remained controversial: effects on pregnancy rates were either positive (8,9) or detrimental (7,(10)(11)(12)(13)(14)(15), with variable P cutoffs. Other investigations failed to demonstrate any correlation between P levels and pregnancy outcome (2,(16)(17)(18)(19)(20)(21).…”