The rapid anti-suicidal ideation effect of ketamine: A systematic review

Hochschild, Annabella; Grunebaum, Michael F.; Mann, J. John

doi:10.1016/j.ypmed.2021.106524

Cited by 30 publications

(10 citation statements)

References 55 publications

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“…Other studies have noted similar results with an emphasis on the efficacy of ketamine in emergency situations for SI reduction 19,20,22,23,26,27 . While Wilkinson et al demonstrated 1 week as the effect duration, Maguire et al did not report significant SI improvements any further than 4 hours post‐infusion; however, the studies in the review by Maguire et al were focused only on patients in the emergency department (ED) setting and were conducted using lower ketamine dosages 22,26 .…”

Section: Resultsmentioning

confidence: 85%

“…In contrast, of three studies regarding esketamine described by both Siegel et al and Lengvenyte et al, two suggested that while esketamine effectively lowers depressive symptoms, the anti‐suicidal effect was not present 25,28 . Another review reported similar results 20 …”

Section: Resultsmentioning

confidence: 95%

“…Overall, 15 included reviews were conducted with suicidal ideation as their primary outcome 13–28 . Twelve of the reviews included studies that were carried out in populations of major depressive disorder (MDD) and/or bipolar depression (BD) adults, with or without treatment‐resistant depression (TRD) 13–28 . The eligibility criteria of the other three reviews only required patients to have baseline suicidal ideation 18,19,22 .…”

Section: Resultsmentioning

confidence: 99%

“…Some studies have highlighted the possibility that the anti‐suicidal effects of ketamine might be independent of its antidepressant properties, mostly given the reduction seen in SI without concurrent antidepressive effects that are seen in some cases 20,21,25,26,31,35,38 …”

Section: Resultsmentioning

confidence: 99%

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Ketamine for suicidality: An umbrella review

Shamabadi

Ahmadzade

Hasanzadeh

2022

Brit J Clinical Pharma

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The urgent need for appropriate treatment for suicide, the tenth leading cause of death, has led to numerous studies. This study aims to systematically identify and appraise systematic reviews with or without meta‐analyses investigating ketamine in suicidal ideation and behaviours. Scopus, ISI, Embase, PubMed, CINAHL, PsycINFO, Cochrane Library, Google Scholar and two registries were searched without any restrictions for systematic reviews investigating the efficacy of ketamine on suicidal ideation and behaviours. The primary outcome was the final inference of ketamine effectiveness. A formal narrative synthesis was conducted, and the AMSTAR‐2 tool was used to evaluate the quality of the studies. Of 27 studies that addressed ketamine for suicidal ideation, only four reported mixed or negative results, and out of nine reviews, esketamine was significantly beneficial only in five. A transient rise in pulse rate and blood pressure, dissociation, confusion, blurred vision, nausea and vertigo were the most common adverse effects; however, most were mild. More than two‐thirds of the included studies qualified as of low or critically low quality. Preliminary evidence for the short‐term efficacy of ketamine in suicidality was noted by the majority of reviews; however, long‐term effects remained unknown. Due to the low quality of many studies and the limitations of core studies, further research is required.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Ketamine for suicidality: An umbrella review

Shamabadi

Ahmadzade

Hasanzadeh

2022

Brit J Clinical Pharma

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“…There is a tendency to include the recreational drug ketamine within the psychedelic group, although it is classified as a dissociative hallucinogen due to its mechanism of action via N‐methyl‐D‐aspartate (NMDA) receptor antagonism and the subjective dissociative nature of its effect 19 . Its enantiomer, esketamine, has been approved for the treatment of treatment-resistant depression 20 and for short‐term management of suicidal thoughts 21 . Ibogaine, an alkaloid similar in structure to the classical psychedelics, has also shown potential in treating addiction to various substances such as opiates and alcohol 22 .…”

Section: Introductionmentioning

confidence: 99%

Validation of a new instrument for assessing attitudes on psychedelics in the general population

Žuljević

Buljan

Leskur

et al. 2022

Sci Rep

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Although there is research interest to assess attitudes on psychedelics, no validated instrument exists for this purpose. We aimed to develop and examine the psychometric properties of the Attitudes on Psychedelics Questionnaire (APQ) in a sample of the Croatian general population. A cross-sectional, web-based survey among the general population was conducted on 1153 participants (62.1% female, 77.7% with a graduate or high school degree, 15.1% health care workers). We assessed participants’ ability to recognize psychedelic substances using a short knowledge test. The APQ consists of 20 items with four sub-scales: Legal Use of Psychedelics, Effects of Psychedelics, Risk Assessment of Psychedelics, and Openness to Psychedelics. This model demonstrated best fit in a confirmatory factor analysis. Total scale reliability was excellent (McDonald’s ω = 0.949, 95% CI = 0.944–0.953). A strong correlation with a similar unvalidated measure (r = 0.885, P < 0.001) demonstrated convergent validity. We observed an association between attitudes and knowledge on psychedelics (r = 0.494, P < 0.001). Younger age, male gender, and lower educational status were associated with higher APQ scores. The APQ is valid, reliable, and could be applied in assessing educational interventions, patients’ treatment outcomes, and the attitudes of different groups of experts. We encourage further validation of the APQ in English.

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