The Rapid Cure of Amoebic Dysentery and Hepatitis by Hypodermic Injections of Soluble Salts of Emetine

Rogers, Leonard

doi:10.1136/bmj.1.2686.1424

Cited by 64 publications

(10 citation statements)

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“…Leonard Rogers designated emetine as the first effective treatment for amebiasis in 1912 (184). In 1913, Walker and Sellards demonstrated the infective cyst form of E. histolytica (228).…”

Section: Background (Historical Perspective)mentioning

confidence: 99%

Laboratory Diagnosis of Amebiasis

2003

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The detection of Entamoeba histolytica, the causative agent of amebiasis, is an important goal of the clinical microbiology laboratory. To assess the scope of E. histolytica infection, it is necessary to utilize accurate diagnostic tools. As more is discovered about the molecular and cell biology of E. histolytica, there is great potential for further understanding the pathogenesis of amebiasis. Molecular biology-based diagnosis may become the technique of choice in the future because establishment of these protozoa in culture is still not a routine clinical laboratory process. In all cases, combination of serologic tests with detection of the parasite (by antigen detection or PCR) offers the best approach to diagnosis, while PCR techniques remain impractical in many developing country settings. The detection of amebic markers in serum in patients with amebic colitis and liver abscess appears promising but is still only a research tool. On the other hand, stool antigen detection tests offer a practical, sensitive, and specific way for the clinical laboratory to detect intestinal E. histolytica. All the current tests suffer from the fact that the antigens detected are denatured by fixation of the stool specimen, limiting testing to fresh or frozen samples

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“…Leonard Rogers designated emetine as the first effective treatment for amebiasis in 1912 (184). In 1913, Walker and Sellards demonstrated the infective cyst form of E. histolytica (228).…”

Section: Background (Historical Perspective)mentioning

confidence: 99%

Laboratory Diagnosis of Amebiasis

2003

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“…Clini¬ cally acetarsone produced the most and carbarsone the least. 4. The use of the arsenicals has not proved detri¬ mental in the treatment of amebic liver abscess.…”

Section: Methods Of Treatmentmentioning

confidence: 99%

Results and Dangers in the Treatment of Amebiasis

Brown¹

1935

JAMA

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“…The root of Cephaelis ipecacuanha [8] and (-)-emetine, one of its active principles [39,44] have been used successfully in the clinical treatment of severe amebiasis for a considerable time. The more recent experience with emetine in the chemotherapy of amebiasis has been reviewed by Craig [9] and by Woolfe [47,48].…”

Section: Discussionmentioning

confidence: 99%

Increased Lifespan of Leukemic Mice Treated with Drugs Related to (–)-Emetine

et al. 1971

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The lifespan of mice bearing ascitic leukemia L1210 could be prolonged by treatment with (-)-emetine dihydrochloride. Optimal dosage schedules required emetine administration daily for 5 days (QD, day 1–5) or intermittently on every 4th day. (Q4D, day 1, 5, 9). Compounds related to (-)-emetine which are active in other biological systems, having the correct stereospecific structure at the C-1′ position in the molecule, a secondary amine structure at N-2′ and an ethyl-group substituent at C-3 were also effective in prolonging the survival time of L1210 leukemic mice. The effective compounds were (-)-cephaeline, (±)-2,3-dehydroemetine, (-)-2,3-dehydroemetine, (-)-tubulosine and (-)-O-methyltubulosine. In contrast, (-)-isoemetine and several derivatives of (±)-2,3-dehydroemetine, lacking the critical configuration at C-1′ or substitution at the N-2′ and C-3 positions in the molecule, were inactive in the mouse leukemia system, when administered according to the Q4D, day 1, 5, 9 schedule.

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The Rapid Cure of Amoebic Dysentery and Hepatitis by Hypodermic Injections of Soluble Salts of Emetine

Cited by 64 publications

References 0 publications

Laboratory Diagnosis of Amebiasis

Laboratory Diagnosis of Amebiasis

Results and Dangers in the Treatment of Amebiasis

Increased Lifespan of Leukemic Mice Treated with Drugs Related to (–)-Emetine

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