The rare HLA-DQA1*03-DQB1*02 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjects

Autreve, Jan E. Van; Weets, Ilse; Gulbis, Béatrice; Vertongen, Françoise; Gorus, Frans; Auwera, Bart J. Van der

doi:10.1016/j.humimm.2004.04.004

Cited by 23 publications

(22 citation statements)

References 39 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We have previously examined celiac disease and the risk of type 1 DM (23) in this cohort. After excluding the first year after celiac disease diagnosis, the risk of later DM in individuals with celiac disease (and no prior DM) was similar to that in any HLA-DQ2-positive individual (29). Considering that a vast majority of individuals with celiac disease are HLA DQ2 positive (28), we suggest that shared HLA is a plausible explanation also for the increased risk of thyroid disease in celiac disease.…”

Section: Discussionmentioning

confidence: 60%

Risk of Thyroid Disease in Individuals with Celiac Disease

Elfström

Montgomery

Kämpe

et al. 2008

The Journal of Clinical Endocrinology &Amp; Metabolism

130

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 60%

Risk of Thyroid Disease in Individuals with Celiac Disease

Elfström

Montgomery

Kämpe

et al. 2008

The Journal of Clinical Endocrinology &Amp; Metabolism

130

View full text Add to dashboard Cite

show abstract

“…ICA were determined by indirect immunofluorescence, IA-2A, GADA and IAA by liquid-phase radiobinding assays and HLA DQ polymorphisms by allele-specific oligonucleotide genotyping as described previously [21,36,37] [22]. HbA1c and random plasma levels of glucose, proinsulin and C-peptide were determined as before [28].…”

Section: Methodsmentioning

confidence: 99%

Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes

Truyen

Grijse

Weets

et al. 2007

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…Approximately one-third of all HLA-DQ2-positive individuals with type 1 diabetes express tissue transglutaminase autoantibodies (8). HLA-DQ2 is a positive risk factor for type 1 diabetes (odds ratio 3.5 in European whites) (38); therefore, the increased risk of type 1 diabetes in celiac disease could be entirely attributable to the HLA characteristics of these individuals. In fact, our risk estimate for subsequent type 1 diabetes is lower than expected, considering that 95% of individuals with celiac disease express HLA-DQ2 (37).…”

Section: Power Calculationmentioning

confidence: 99%

Celiac Disease and Risk of Subsequent Type 1 Diabetes

et al. 2006

View full text Add to dashboard Cite

OBJECTIVE—Earlier studies suggest that children with type 1 diabetes are more likely to have a subsequent diagnosis of celiac disease. However, research is sparse on the risk of subsequent type 1 diabetes in individuals with celiac disease. We sought to determine the risk of subsequent type 1 diabetes diagnosed before the age of 20 years in children and adolescents with celiac disease in a national, general population–based cohort. RESEARCH DESIGN AND METHODS—We identified 9,243 children with a diagnosis of celiac disease in the Swedish national inpatient register between 1964 and 2003. We then identified five reference individuals matched at time of diagnosis for age, calendar year, sex, and county (n = 45,680). Only individuals with >1 year of follow-up after study entry (diagnosis of celiac disease) were included in the analyses. RESULTS—Celiac disease was associated with a statistically significantly increased risk of subsequent type 1 diabetes before age 20 years (hazard ratio 2.4 [95% CI 1.9–3.0], P < 0.001). This risk increase was seen regardless of whether celiac disease was first diagnosed between 0 and 2 (2.2 [1.7–2.9], P < 0.001) or 3 and 20 (3.4 [1.9–6.1], P < 0.001) years of age. Individuals with prior celiac disease were also at increased risk of ketoacidosis or diabetic coma before the age of 20 years (2.3 [1.4–3.9], P = 0.001). CONCLUSIONS—Children with celiac disease are at increased risk of subsequent type 1 diabetes. This risk increase is low considering that 95% of individuals with celiac disease are HLA-DQ2 positive.

show abstract

The rare HLA-DQA103-DQB102 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjects

Cited by 23 publications

References 39 publications

Risk of Thyroid Disease in Individuals with Celiac Disease

Risk of Thyroid Disease in Individuals with Celiac Disease

Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes

Celiac Disease and Risk of Subsequent Type 1 Diabetes

Contact Info

Product

Resources

About