2013
DOI: 10.1302/2046-3758.28.2000171
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The rat model of femur fracture for bone and mineral research

Abstract: ObjectivesOne commonly used rat fracture model for bone and mineral research is a closed mid-shaft femur fracture as described by Bonnarens in 1984. Initially, this model was believed to create very reproducible fractures. However, there have been frequent reports of comminution and varying rates of complication. Given the importance of precise anticipation of those characteristics in laboratory research, we aimed to precisely estimate the rate of comminution, its importance and its effect on the amount of sof… Show more

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Cited by 17 publications
(30 citation statements)
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“…We aimed to develop a standardized, reproducible, and clinically relevant multiple trauma mouse model of chest trauma [ 13 ] and femur fracture [ 14 ] to investigate the pathophysiologic changes, especially cytokine expression, after multiple trauma. Both methods have been evaluated in isolation in several studies and described as reproducible [ 15 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…We aimed to develop a standardized, reproducible, and clinically relevant multiple trauma mouse model of chest trauma [ 13 ] and femur fracture [ 14 ] to investigate the pathophysiologic changes, especially cytokine expression, after multiple trauma. Both methods have been evaluated in isolation in several studies and described as reproducible [ 15 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…Five ( n = 5) rats were sacrificed at each time point, namely at 1st, 2nd, 3rd, 4th, and 6th week post-surgery. Gross callus index and callus area size were determined from the dissected fracture tibiae and the control (Greiff, 1978 ; Otto et al, 1995 ; Eastaugh-Waring et al, 2009 ; Aurégan et al, 2013 ). A dissecting stereo-microscope (HUVITZ; HSZ-645TR, Korea) fitted to a 3.1 M pixel digital camera (VIS Imaging UC3010, Malaysia) (millimeter unit of measurement) was used to capture dissected bone images and measure the callus width (mm) of the rat left tibial fracture healing with callus formed.…”
Section: Methodsmentioning
confidence: 99%
“…Three types of comminution were to be observed: firstly, no comminution (no third fragment) is detected on the two radiological observation views of anterioposterior and lateral; secondly, slight comminution with smaller fragments where the size is smaller than the pin diameter, i.e. < 1.1 mm, and thirdly, severe comminution (≥ one large fragment larger than the diameter of the intramedullary pin) (Aurégan et al, 2013 ).…”
Section: Methodsmentioning
confidence: 99%
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