The rate enhancing effect of ultrasound by inducing supersaturation in a solid–liquid system

Thompson, L. H.; Doraiswamy, L. K.

doi:10.1016/s0009-2509(99)00481-9

Cited by 93 publications

(38 citation statements)

References 7 publications

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“…When ultrasound is applied to the system, the ultrasonic power will accelerate diffusion and increase D AB . Ultrasound may also influence the solubility, which will influence the supersolubility as well (Thompson et al, 2000). If the heat cannot be removed immediately, the hot points may influence the local temperature.…”

Section: Resultsmentioning

confidence: 99%

The effect of ultrasound on the homogeneous nucleation of BaSO4 during reactive crystallization

Guo

Jones

2006

Chemical Engineering Science

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Section: Resultsmentioning

confidence: 99%

The effect of ultrasound on the homogeneous nucleation of BaSO4 during reactive crystallization

Guo

Jones

2006

Chemical Engineering Science

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“…When ultrasound is applied to the system, the ultrasonic power will accelerate diffusion and increase the diffusion coefficient (D AB ). From Thompson and Doraiswamy [13], ultrasound may influence the solubility and therefore the supersolubility. The hot point may influence the local temperature, if the heat cannot be removed immediately.…”

Section: Theorymentioning

confidence: 99%

Effect of ultrasound on anti-solvent crystallization process

Guo

Zhang

et al. 2005

Journal of Crystal Growth

196

114

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“…Ratsimba et al [1999] have documented a review on sonocrystallization. Thompson and Doraiswamy [2000] have reported an increase in the solubility of sparingly soluble solids when subjected to ultrasound.…”

Section: Introductionmentioning

confidence: 99%

Improvement of physicochemical and biopharmaceutical properties of flurbiprofen using melt sonocrystallization technique

El-Kamel

2008

Drug Development Research

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The aim of the present study was to investigate the suitability of the melt sonocrystallization technique to modify the undesirable properties of the nonsteroidal anti-inflammatory drug (NSAID), flurbiprofen (FBP), e.g., poor flowability, solubility, and dissolution rate and, consequently, poor bioavailability. FBP melt was poured in deionized water at 251C and sonicated for 4 min at an amplitude of 60% and cycle of 40 s on and 10 s off. The product obtained was evaluated using scanning electron microscopy (SEM), image analysis, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), and X-ray powder diffraction (XRPD). Flow properties, intrinsic dissolution rate, solubility, and bioavailability were also evaluated. The particle size of the treated FBP was significantly reduced. Thermal behavior and FT-IR spectra of untreated and treated FBP have shown no significant difference. Low-intensity peaks in the X-ray diffraction of treated FBP were noticed. In addition there was significant enhancement in the flow properties of treated FBP, as indicated by the value of angle of repose and the flow constants calculated from the Kawakita equation. The increased solubility of treated FBP was about 35%. The intrinsic dissolution rate of treated FBP increased by 2-fold. The dissolution rate studies revealed that 90% of the drug was released within 20 min for treated FBP compared with 60% released for the untreated drug. The relative bioavailability of treated FBP was increased by 2-fold compared with untreated drug.The use of melt sonocrystallization technique is a promising technique that may afford powder with improved flow and tablet functionality as well as improved dissolution and bioavailability. Drug Dev Res 69: [34][35][36][37][38][39][40][41] 2008 r2008 Wiley-Liss, Inc.

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The rate enhancing effect of ultrasound by inducing supersaturation in a solid–liquid system

Cited by 93 publications

References 7 publications

The effect of ultrasound on the homogeneous nucleation of BaSO4 during reactive crystallization

The effect of ultrasound on the homogeneous nucleation of BaSO4 during reactive crystallization

Effect of ultrasound on anti-solvent crystallization process

Improvement of physicochemical and biopharmaceutical properties of flurbiprofen using melt sonocrystallization technique

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