The Rate of Fall of Arterial Oxyhemoglobin Saturation in Obstructive Sleep Apnea

Fletcher, Eugene C.; Costarangos, Constantino; Miller, Trey

doi:10.1378/chest.96.4.717

Cited by 46 publications

(18 citation statements)

References 17 publications

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“…The second line of the two-slope datafitting method represents the slope of the arterial desaturation (⌬SaO 2 /⌬t) (13,14,20,23,30). A significant group effect was noted for the ⌬SaO 2 /⌬t (trained ϭ Ϫ0.14 Ϯ 0.04 %⅐s Ϫ1 , untrained ϭ Ϫ0.11 Ϯ 0.05%⅐s Ϫ1 , P ϭ 0.015); however, this straight line fitting underestimates the rate of decline in untrained subjects because the ⌬SaO 2 /⌬t never reaches a consistent rate of change as observed in trained apnea divers.…”

Section: Resultsmentioning

confidence: 99%

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Arterial Oxygen Desaturation Kinetics during Apnea

Stewart

Bulmer

Sharman

et al. 2005

Medicine &Amp; Science in Sports &Amp; Exercise

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Section: Resultsmentioning

confidence: 99%

“…The ⌬SaO 2 /⌬t has previously been calculated by manually drawing a line adjacent to the falling portion of the SaO 2 curve (13,20), or by drawing a line between two prechosen time points, irrespective of intermediary data points (23). These methods are appropriate if a significant linear falling portion of the SaO 2 curve is observable.…”

Section: Discussionmentioning

confidence: 99%

Arterial Oxygen Desaturation Kinetics during Apnea

Stewart

Bulmer

Sharman

et al. 2005

Medicine &Amp; Science in Sports &Amp; Exercise

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“…The condition is characterized by frequent episodes of apnoea and hypopnoea during sleep, which lead to the fragmentation of sleep and to decreases in oxyhaemoglobin saturation [3,4]. As a consequence, patients are at increased risk of cardiovascular morbidity and mortality [5], and are more frequently involved in traffic accidents [6].…”

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confidence: 99%

Diagnostic accuracy of a portable recording device (MESAM IV) in suspected obstructive sleep apnoea

Esnaola

Durán²,

Infante‐Rivard³

et al. 1996

Eur Respir J

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D Di ia ag gn no os st ti ic c a ac cc cu ur ra ac cy y o of f a a p po or rt ta ab bl le e r re ec co or rd di in ng g d de ev vi ic ce e ( (M ME ES SA AM M I IV V) ) i in n s su us sp pe ec ct te ed d o ob bs st tr ru uc ct ti iv ve e s sl le ee ep p a ap pn no oe ea a S. Esnaola*, J. Durán**, C. Infante-Rivard + , R. Rubio**, A. Fernández + Diagnostic accuracy of a portable recording device (MESAM IV) in suspected obstructive sleep apnoea. S. Esnaola, J. Durán, C. Infante-Rivard, R. Rubio, A. Fernández. ERS Journals Ltd 1996. ABSTRACT: This study evaluated the accuracy of a portable recording device (MESAM IV) in identifying obstructive sleep apnoea (OSA).The MESAM IV system measures arterial oxygen saturation (Sa,O 2 ), heart rate, snoring sounds and body position, and allows both automatic and manual scoring of the recordings. Nocturnal polysomnography and MESAM IV recordings were performed simultaneously in 150 patients with suspected OSA, and were analysed blindly by a different observer. Patients with an apnoea-hypopnoea index (AHI) greater than or equal to 10 were diagnosed as having OSA. In the evaluation of the discriminatory ability of MESAM IV scores, the cut-off point was set to minimize first the exclusion of truly diseased patients (i.e. false-negative interpretations), and then the confirmation of nondiseased subjects (i.e. false-positives).When used as an exclusion test, the portable device reached a sensitivity of 0.98 and a specificity of 0.78; as a confirmation test, these values were 0.69 and 0.97, respectively. These results were achieved with manual scoring, which was superior to automatic scoring. Manual scoring was also better than automatic scoring when OSA was defined according to other threshold values (≥5, 15 and 20) for the AHI.The combination of MESAM IV manual scores could reduce the need for diagnostic polysomnography in three quarters of the patients clinically suspected of having obstructive sleep apnoea, substantially reducing costs associated with diagnostic procedures.

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“…Subsequently, studies by our group (Wilkinson et al, 1995) and others (Fletcher et al, 1989a(Fletcher et al, , 1989bShepard, 1985) provided evidence to suggest that following apnea, mixed-venous O 2 is slow to recover, an effect which strongly accelerates desaturation rate during a subsequent apnea (Wilkinson et al, 1995). Such an acceleration of desaturation occurs throughout the period prior to arterial-venous equilibrium, which we refer to as stage 1 of the desaturation process (Wilkinson et al, 1995); in contrast, the current study found that V/Q mismatch hastens desaturation only at the onset of apnea, in the early phase of stage 1.…”

Section: Implications For Recurrent Apneamentioning

confidence: 97%