2022
DOI: 10.1016/j.dnarep.2022.103300
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The rate of formation and stability of abasic site interstrand crosslinks in the DNA duplex

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Cited by 6 publications
(7 citation statements)
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“…Other than the observations provided above, the effects of local sequence on the ICL yield generated in duplexes containing the dA-AP sequence motif are cryptic. Nonetheless, our findings, alongside earlier results ,,,, clearly demonstrate that the dA-AP ICL can form in a wide variety of sequence contexts. Indeed, the majority of the sequences examined here generated equilibrium ICL yields of 15% or more, and relatively few sequences produced ICL yields below 5%.…”
Section: Resultssupporting
confidence: 86%
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“…Other than the observations provided above, the effects of local sequence on the ICL yield generated in duplexes containing the dA-AP sequence motif are cryptic. Nonetheless, our findings, alongside earlier results ,,,, clearly demonstrate that the dA-AP ICL can form in a wide variety of sequence contexts. Indeed, the majority of the sequences examined here generated equilibrium ICL yields of 15% or more, and relatively few sequences produced ICL yields below 5%.…”
Section: Resultssupporting
confidence: 86%
“…In most previous studies, formation of the dA-AP ICL was carried out in HEPES buffer (50 mM, pH 7.4) containing 100 mM NaCl. ,, Here we examined time-courses for cross-link formation in several different buffers and at pH values between 5 and 8.…”
Section: Resultsmentioning
confidence: 99%
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“…An aldehyde group of the ring-opened ribose at C1′ forms an N -glycosidic bond with an amine group of a base in the opposite DNA strand ( 9 , 10 ). It is noteworthy that a stable and specific Ap-ICL forms between an Ap site and an adenine in the opposite strand within the 5′-Ap-dT-3′ sequence ( 11 , 12 ).…”
Section: Introductionmentioning
confidence: 99%