The rate of gas-soluble growth in tissue under decompression. Mathematical modelling

Kislyakov, Yu. Ya.; Kopyltsov, A. V.

doi:10.1016/0034-5687(88)90023-0

Cited by 11 publications

(7 citation statements)

References 4 publications

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“…When chemical stimuli, such as hypoxia and hypercapnia (elevated CO 2 level in the blood), are recognized by chemoreceptors, the respiratory center increases the flow of impulses to the respiratory motor neurons, which results in increased ventilation. Arterial hypocapnia (low CO 2 levels), on the contrary, causes a decrease in ventilation [ 41 , 42 ]. In the case of SARS-CoV-2 virus infection, impaired CO 2 excretion through exhaled air leads to stimulation of hyperventilation to reduce CO 2 concentration.…”

Section: Physiological Aspects Of the Compensatory Mechanisms Of Acidosismentioning

confidence: 99%

The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19

Nechipurenko

Semyonov

Lavrinenko

et al. 2021

Biology

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COVID-19 has specific characteristics that distinguish this disease from many other infections. We suggest that the pathogenesis of severe forms of COVID-19 can be associated with acidosis. This review article discusses several mechanisms potentially linking the damaging effects of COVID-19 with acidosis and shows the existence of a vicious cycle between the development of hypoxia and acidosis in COVID-19 patients. At the early stages of the disease, inflammation, difficulty in gas exchange in the lungs and thrombosis collectively contribute to the onset of acidosis. In accordance with the Verigo-Bohr effect, a decrease in blood pH leads to a decrease in oxygen saturation, which contributes to the exacerbation of acidosis and results in a deterioration of the patient’s condition. A decrease in pH can also cause conformational changes in the S-protein of the virus and thus lead to a decrease in the affinity and avidity of protective antibodies. Hypoxia and acidosis lead to dysregulation of the immune system and multidirectional pro- and anti-inflammatory reactions, resulting in the development of a “cytokine storm”. In this review, we highlight the potential importance of supporting normal blood pH as an approach to COVID-19 therapy.

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Section: Physiological Aspects Of the Compensatory Mechanisms Of Acidosismentioning

confidence: 99%

The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19

Nechipurenko

Semyonov

Lavrinenko

et al. 2021

Biology

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“…Bubble generation and growth in liquids plays a key role in diverse fields of technology such as polymer (foam molding) and glass processing, flotation separations, pumps, and hydraulic power recovery systems (for example, Arefmanesh et al, 1992; Clift et al, 1978; Payvar, 1987; Yoo and Han, 1982). It also plays an important role in human physiology, such as blood oxygenation, bubbles growing in the tissue of airplane passengers, astronauts, and divers during decompression (for example, Foster et al, 2000; Kislyakov and Kopyltsov, 1988; Srinivasan et al, 2000; Van Liew et al, 1995). In addition, it is of critical value in studying physical phenomena such as cavitation, nucleation, and boiling (for example, Arefmanesh et al, 1991; Lee and Merte, 1996a,b; Plesset and Sadhal, 1982; Straub, 2000).…”

Section: Introductionmentioning

confidence: 99%

Bubbles growing in supersaturated solutions at reduced gravity

et al. 2004

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“…plastic foam manufacturing (Arefmanesh et al, 1990;Yoo and Han, 1982), human physiology, e.g. blood oxygenation, bubble growing in the tissue of airplane passengers, hypobaric and hyperbaric decompression of astronauts and divers, respectively (Kislyakov and Kopyltsov, 1988;Van Liew and Burkard, 1995;Srinivasan et al, 2000), geology, e.g. volcanic eruptions due to magma degassing (Prousevitch et al, 1983;Blower et al, 2001), food technology (Barker et al, 2002).…”

Section: Introductionmentioning

confidence: 99%