The rate of mitotic activity in the lymphoid organs of the rat

Andreasen, Erik; Christensen, Søren T.

doi:10.1002/ar.1091030307

Cited by 69 publications

(15 citation statements)

References 12 publications

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“…The results have confirmed the earlier observations of Kindred (1940) and Andreasen and Christensen (1949) that the mouse thymus is an intensely active site of lymphopoiesis.…”

Section: Discussionsupporting

confidence: 91%

Quantitative Cytological Studies on Thymic Lymphoid Cells in Normal, Preleukaemic and Leukaemic Mice

Nakamura¹,

Metcalf²

1961

Br J Cancer

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THE incidence of spontaneous thymic lymphomata, with generalised lymphoid leukaemia, in AKR mice varies from [85][86][87][88][89][90][91][92][93][94][95] per cent. The first histological and biological evidence of leukaemia is usually to be found in the thymus, and the disease is commonly limited to the thymus (Furth and Boon, 1945). The first deaths from this disease usuafly occur in female mice at six months, and in male mice at seven months of age.The AKR thymus therefore presents an ideal opportunity for a detailed cytological examination of the preleukaemic state. In the sense used in this paper, " preleukaemic " refers merely to AKR mice in the 0-7 months age period.This paper presents the results of a comparative survey of AKR and C3H thymuses in this age period. MATERIALS AND METHODS MiceMice used were inbred males and females of strains AKR and C3H.

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“…The results have confirmed the earlier observations of Kindred (1940) and Andreasen and Christensen (1949) that the mouse thymus is an intensely active site of lymphopoiesis.…”

Section: Discussionsupporting

confidence: 91%

Quantitative Cytological Studies on Thymic Lymphoid Cells in Normal, Preleukaemic and Leukaemic Mice

Nakamura¹,

Metcalf²

1961

Br J Cancer

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“…The lymphocytes in the blood arc derived from the thymus and lymphatic tissue (Kindred [1942], Andreasen and Ottesen [1945], Andreasen and Christensen [1949]). Many investigations have been carried out to compare the lymphocytes in the thymus and those in the blood.…”

Section: A Difference Between Lymph Nodal and Thymic Lymphocytes Showmentioning

confidence: 99%

A Difference Between Lymph Nodal and Thymic Lymphocytes Shown by Transfusion of Labelled Cells

Fichtelius¹

1958

Cells Tissues Organs

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“…The stains of thymic lymphocytes, which was considered to be red cells-free, showed also obviously positive results. A little difference in mitotic activity between thymic lymphocytes and blood lymphocytes was pointed out (Andreason and Christensen 1949), but these had essentially the same serological property. In the previous paper , the detectable maximum dilutions of the blood red cells were calculated as follows; 1: 50 for M and N group red cells and 1: 25 for M and N antigens of MN group red cells.…”

Section: Resultsmentioning

confidence: 95%

MN Blood Group Activity of the Blood Components Other Than the Red Cells

Sagisaka

Tokiwa

1973

Tohoku J. Exp. Med.

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The presence of M and N antigens in the blood components other than the red cells and various tissues has not been settled yet . The elution method in combination with antiglobulin test reported by the present authors has been used for grouping the stains of the leucocytes , platelets, fibrin, and thymic lympho cytes. All of the test-stains showed obviously positive antigen activities which coincided with blood group of the sources. The experiments of the test-stains treated with trypsin revealed that the treated stains showed a similar agglutin ability to that of the treated red cells. From the results, it is concluded that the blood components have M or N antigen activity which is a little lower than the red cells.MMIN blood group; leucocytes; platelet; fibrin; lymphocytes It has been well admitted that M and N group antigens are on the blood red cells. As regards the blood components other than red cells and various tissues, there are two antagonistic opinions: Boorman and Dodd (1943), Kosyakov and Kuznetsova (1962) and Majsky (1960) reported that M and N group antigens were contained in various human tissues, whereas Clausen (1933) and Krah (1952) pointed out that the antigens were demonstrated only in the blood red cells. Recently, serological techniques to detect antigens or antibodies have been remarkably ameliorated. For example, the mixed agglutination or the groupspecific double combination method (Coombs and Dodd 1961, Akaishi 1965), and the absorption-elution method (Kind 1960;Yada 1962) are able to demonstrate easily the blood group of minute saliva stains belonging to non-secretor, which cannot be detected with the agglutination inhibition test. The present authors reported previously ) an improved method for MN blood grouping, which is a modified elution method in combination with anti-globulin test, and MN blood groups of very minute stains, even 2-to 3-year-old, were detected by this method. The present paper deals with M and N antigens of the leucocytes, platelets, fibrin and thymic lymphocytes. MATERIALS AND METHODSTest-stains of the leucocytes, platelets, fibrin, and thymic lymphocytes. Each of M, N and MN group blood containing standard acid-citrate-dextrose was centrifuged at 1,300

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The rate of mitotic activity in the lymphoid organs of the rat

Cited by 69 publications

References 12 publications

Quantitative Cytological Studies on Thymic Lymphoid Cells in Normal, Preleukaemic and Leukaemic Mice

Quantitative Cytological Studies on Thymic Lymphoid Cells in Normal, Preleukaemic and Leukaemic Mice

A Difference Between Lymph Nodal and Thymic Lymphocytes Shown by Transfusion of Labelled Cells

MN Blood Group Activity of the Blood Components Other Than the Red Cells

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