The ratio FEV<sub>1</sub>/FVC and its association to respiratory symptoms—A Swedish general population study

Schiöler, Linus; Lindberg, Anne; Andersson, Anders; Behndig, Annelie F.; Bergström, Göran; Blomberg, Anders; Caidahl, Kenneth; Engvall, Jan; Eriksson, Maria; Hamrefors, Viktor; Janson, Christer; Kylhammar, David; Lindberg, Eva; Lindén, Anders; Malinovschi, Andreï; Persson, Hans Lennart; Sandelin, Martin; Ström, Jonas Eriksson; Tanash, Hanan; Vikgren, Jenny; Östgren, Carl Johan; Wollmer, Per; Sköld, C. Magnus

doi:10.1111/cpf.12684

Cited by 12 publications

(5 citation statements)

References 35 publications

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“…The FEV 1 :FVC ratio has been used as a screening index for identifying obstructive lung conditions globally, 37 as a lower FEV 1 owing to obstruction of air escaping from the lungs will reduce the FEV 1 :FVC ratio. Transgender women’s results ( figure 2C ) suggest obstructed airflow in the lungs 38 when compared with cisgender women. However, this observation of transgender women is unlikely to be pathological (<0.70), 39 as seen in chronic obstructive pulmonary disease.…”

Section: Discussionmentioning

confidence: 95%

Strength, power and aerobic capacity of transgender athletes: a cross-sectional study

Hamilton,

Brown,

Montagner-Moraes

et al. 2024

Br J Sports Med

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ObjectiveThe primary objective of this cross-sectional study was to compare standard laboratory performance metrics of transgender athletes to cisgender athletes.Methods19 cisgender men (CM) (mean±SD, age: 37±9 years), 12 transgender men (TM) (age: 34±7 years), 23 transgender women (TW) (age: 34±10 years) and 21 cisgender women (CW) (age: 30±9 years) underwent a series of standard laboratory performance tests, including body composition, lung function, cardiopulmonary exercise testing, strength and lower body power. Haemoglobin concentration in capillary blood and testosterone and oestradiol in serum were also measured.ResultsIn this cohort of athletes, TW had similar testosterone concentration (TW 0.7±0.5 nmol/L, CW 0.9±0.4 nmol/), higher oestrogen (TW 742.4±801.9 pmol/L, CW 336.0±266.3 pmol/L, p=0.045), higher absolute handgrip strength (TW 40.7±6.8 kg, CW 34.2±3.7 kg, p=0.01), lower forced expiratory volume in 1 s:forced vital capacity ratio (TW 0.83±0.07, CW 0.88±0.04, p=0.04), lower relative jump height (TW 0.7±0.2 cm/kg; CW 1.0±0.2 cm/kg, p<0.001) and lower relative V̇O2max (TW 45.1±13.3 mL/kg/min/, CW 54.1±6.0 mL/kg/min, p<0.001) compared with CW athletes. TM had similar testosterone concentration (TM 20.5±5.8 nmol/L, CM 24.8±12.3 nmol/L), lower absolute hand grip strength (TM 38.8±7.5 kg, CM 45.7±6.9 kg, p=0.03) and lower absolute V̇O2max (TM 3635±644 mL/min, CM 4467±641 mL/min p=0.002) than CM.ConclusionWhile longitudinal transitioning studies of transgender athletes are urgently needed, these results should caution against precautionary bans and sport eligibility exclusions that are not based on sport-specific (or sport-relevant) research.

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Section: Discussionmentioning

confidence: 95%

Strength, power and aerobic capacity of transgender athletes: a cross-sectional study

Hamilton,

Brown,

Montagner-Moraes

et al. 2024

Br J Sports Med

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“…Generally, FEV1/FVC ratio is considered useful to evaluate lung functions. [ 46 ] Pulse oximetry estimates the oxygen saturation in the blood that helps replace worn-out cells, supplies energy, and supports the immune system. It also feeds our brain and helps in visual, cognitive, and electroencephalographic function.…”

Section: Introductionmentioning

confidence: 99%

Quest for Biomarkers of Positive Health: A Review

Indrayan

Vishwakarma

Verma

et al. 2023

Indian Journal of Community Medicine

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The positive health of a person can be defined as the ability to live long in good health, possibly with no activity limitation. No method is yet available for its objective assessment in individuals, and we propose a framework in this communication that can operationalize this concept. Instead of distal factors, such as diet and lifestyle because these are subjective and difficult to measure, we concentrate on the objectively measurable biomarkers such as immunity level, endorphins, and handgrip strength. The focus is on the major parameters that may protect from diseases and infirmity and can be assessed by noninvasive methods. A combination of such parameters may signify positive health. This may be a novel way to measure positive health at the individual level. In this communication, we briefly review the literature and identify a few major biomarkers that provide a protective shield and could determine the status of positive health at the individual level. This exercise demonstrates that the assessment of the positive health of a person is feasible. A scale based on these and other relevant parameters can be developed later that could quantitatively measure the exact level of positive health. As the exact combination of the parameters that protects from ailments is not fully known yet, a framework such as this may help in identifying the data gaps that require attention in this context. The proposed framework may initiate a discussion on indicators of positive health and characterize the parameters for intervention that could increase a healthy life.

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“…The effects of pollution on subjective wellbeing and quality of life [ 4 ], in particular, can be assessed non-invasively using self-reported symptoms questionnaires [ 5 – 7 ]. Symptoms are also robust indicators of the pollution-associated exacerbation of cardiopulmonary diseases [ 6 , 8 – 10 ] and are correlated with other clinical health measures, such as fractional exhaled nitric oxide (FeNO) [ 11 ] and forced expiratory volume in 1 s (FEV 1 ) [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Concentration-dependent increase in symptoms due to diesel exhaust in a controlled human exposure study

et al. 2022

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Background Traffic-related air pollution (TRAP) exposure causes adverse effects on wellbeing and quality of life, which can be studied non-invasively using self-reported symptoms. However, little is known about the effects of different TRAP concentrations on symptoms following controlled exposures, where acute responses can be studied with limited confounding. We investigated the concentration–response relationship between diesel exhaust (DE) exposure, as a model TRAP, and self-reported symptoms. Methods We recruited 17 healthy non-smokers into a double-blind crossover study where they were exposed to filtered air (FA) and DE standardized to 20, 50, 150 µg/m3 PM2.5 for 4 h, with a ≥ 4-week washout between exposures. Immediately before, and at 4 h and 24 h from the beginning of the exposure, we administered visual analog scale (VAS) questionnaires and grouped responses into chest, constitutional, eye, neurological, and nasal categories. Additionally, we assessed how the symptom response was related to exposure perception and airway function. Results An increase in DE concentration raised total (β ± standard error = 0.05 ± 0.03, P = 0.04), constitutional (0.01 ± 0.01, P = 0.03) and eye (0.02 ± 0.01, P = 0.05) symptoms at 4 h, modified by perception of temperature, noise, and anxiety. These symptoms were also correlated with airway inflammation. Compared to FA, symptoms were significantly increased at 150 µg/m3 for the total (8.45 ± 3.92, P = 0.04) and eye (3.18 ± 1.55, P = 0.05) categories, with trends towards higher values in the constitutional (1.49 ± 0.86, P = 0.09) and nasal (1.71 ± 0.96, P = 0.08) categories. Conclusion DE exposure induced a concentration-dependent increase in symptoms, primarily in the eyes and body, that was modified by environmental perception. These observations emphasize the inflammatory and sensory effects of TRAP, with a potential threshold below 150 µg/m3 PM2.5. We demonstrate VAS questionnaires as a useful tool for health monitoring and provide insight into the TRAP concentration–response at exposure levels relevant to public health policy.

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The ratio FEV₁/FVC and its association to respiratory symptoms—A Swedish general population study

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 12 publications

References 35 publications

Strength, power and aerobic capacity of transgender athletes: a cross-sectional study

Strength, power and aerobic capacity of transgender athletes: a cross-sectional study

Quest for Biomarkers of Positive Health: A Review

Concentration-dependent increase in symptoms due to diesel exhaust in a controlled human exposure study

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The ratio FEV1/FVC and its association to respiratory symptoms—A Swedish general population study

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 12 publications

References 35 publications

Strength, power and aerobic capacity of transgender athletes: a cross-sectional study

Strength, power and aerobic capacity of transgender athletes: a cross-sectional study

Quest for Biomarkers of Positive Health: A Review

Concentration-dependent increase in symptoms due to diesel exhaust in a controlled human exposure study

Contact Info

Product

Resources

About

The ratio FEV₁/FVC and its association to respiratory symptoms—A Swedish general population study