The ratio Neutrophil/Lymphocyte and Platelet/Lymphocyte in patient with Rheumatoid Arthritis that are Treating with Anti-TNF

Boyraz, İsmail; Boyacı, Ahmet; Koç, Bünyamin; Tutoğlu, Ahmet; Sarman, Hakan; Özkan, Hilal; Güven, Umut

doi:10.15824/actamedica.19182

Cited by 44 publications

(58 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[18] Another study by Sula et al reported that PLR and PDW values were higher in patients with leishmaniasis compared to the control subjects. [19] In our study, we found that lymphocyte was higher and PLR values were significantly lower in the patient group.…”

Section: Discussionmentioning

confidence: 95%

The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

Sarıca¹,

Bilal²,

Orhan³

et al. 2017

ENT Updates

View full text Add to dashboard Cite

Lymphadenopathies constitute most of the neck masses of the children. Lymph nodes are arranged along the lymphatic canal. They are rich in lymphocytes and antigenpresenting cells and surrounded by a fibrous capsule. Lymph node enlargement in local and systemic infectious cases is seen as lymphadenomegaly or lymphadenopathy Yöntem: Muayene s›ras›nda saptanan herhangi bir neden olmaks›z›n boyunda fliflme flikayetiyle 2014 ile 2017 y›llar› aras›nda KBB klini¤i-ne kabul edilen ve idiyopatik patolojik LAP tan›s› konulan toplam 100 çocuk retrospektif çal›flmaya dahil edildi. Kontrol grubu herhangi bir enfeksiyonu olmayan ve muayene ve laboratuvar tahlillerine göre sa¤-l›kl› oldu¤u düflünülen 100 çocuktan oluflmaktayd›. Hastalar ve kontrol grubu klinikteki hasta kay›tlar›na bak›larak yafl, cinsiyet, klinik öykü, hastal›k süreci ve muayene bulgular› aç›s›ndan tarand›. Bulgular:Hasta grubunda ortalama lökosit ve lenfosit say›lar› kontrol grubundan daha yüksek olup farkl›l›k istatistiksel olarak anlaml›yd› (s›ra-s›yla p=0.008 ve p=0.001). Hasta grubunda ortalama NLO ve TLO de¤erleri kontrol grubuna göre anlaml› derecede daha düflüktü (s›ras›yla p=0.009 ve p=0.020). Sonuç:Bilinmeyen etiyolojili patolojik servikal LAP nedeniyle takip edilen çocuklarda NLO ve TLO enflamasyonla iyi bir korelasyon gös-terebilir.Anahtar sözcükler: Nötrofil/lenfosit orant›s›, trombosit/lenfosit orant›s›, lenfadenopati. AbstractObjective: To reveal whether if neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) rates are useful or not in children followed-up due to pathological cervical lymphadenopathy (LAP) of unknown etiology who have a normal hematologic examination. Methods:A total of 100 children admitted to the otorhinolaryngology clinic between 2014 and 2017 with the complaint of swelling in the neck without any etiology revealed on examination and established with the diagnosis of idiopathic pathological LAP were retrospectively included in the study. The control group consisted of 100 children who did not have any infectious condition and could be considered healthy in terms of examination and laboratory findings. Patients' and the control group's age, gender, clinical history, disease course and examination findings were screened from the patients' records in the clinic. Results:Mean white blood cell and lymphocyte count parameters in the patient group were higher than the control group, and the difference was statistically significant (p=0.008 and p=0.001, respectively). In the patient group, mean NLR and PLR values were significantly lower than the control group (p=0.009 and p=0.020, respectively).Conclusion: NLR and PLR rates may be well correlated with inflammation in children followed-up due to pathologic cervical LAP with unknown etiology.

show abstract

Section: Discussionmentioning

confidence: 95%

The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

Sarıca¹,

Bilal²,

Orhan³

et al. 2017

ENT Updates

View full text Add to dashboard Cite

show abstract

“…In fact, a relationship between PLR and colorectal cancer, non-small cell lung cancer, and acute coronary syndrome has been reported [11–13], and PLR is considered to be a prognostic indicator of tumor diseases. Kultigin et al [15] reported that PLR is better than NLR for the predictive value of end-stage renal disease.…”

Section: Discussionmentioning

confidence: 99%

“…Several lines of evidence now attest that the platelet to lymphocytes ratio (PLR) is associated with outcomes of patients with ankylosing spondylitis, non-small cell lung cancer, and acute coronary syndrome [11–13]. Inflammation may be a hidden factor that explains the correlation between NLP, PLR, and those diseases.…”

mentioning

confidence: 99%

Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in patients with rheumatoid arthritis

et al. 2015

View full text Add to dashboard Cite

ObjectivesIt has been well documented that the platelet to lymphocyte ratio (PLR) and the neutrophil to lymphocyte ratio (NLR) are associated with outcomes for patients with gastric cancer, non-small cell lung cancer and acute heart failure. Inflammation may be the hidden factor that explains the correlation between NLP, PLR, and these diseases. However, to date, the data concerning NLR, PLR, and its association with inflammation are lacking in patients with rheumatoid arthritis (RA), thus, our aim to discuss whether NLR and PLR are associated with RA.MethodsPatients with RA and healthy individuals were included according to the determined criteria, and laboratory indicators were measured.ResultsPLR and NLR were significantly higher in RA patients compared with healthy controls (3.20±2.06 vs. 1.56±0.47, P<0.01; 192.85±101.78 vs. 103.49±28.68, P<0.01). When leukocytes, neutrophil percentage, neutrophil, lymphocyte, platelet, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF) were considered as confounders (crude model), our results indicated that ESR and RF were correlated to RA. Of note, ESR, RF, and PLR were associated with RA after further adjustment based on crude model for PLR and NLR. Receiver operating characteristic (ROC) curves analysis showed that PLR values higher than >115.7 evaluated RA with a sensitivity of 82.5%, a specificity of 74.8% and area under the curve ( AUC ) of 0.847.ConclusionsOur results suggest that PLR is associated with RA, and PLR may be an underlying indicator indicating the chronic subclinical inflammation in patients with RA.

show abstract

“…NLR and PLR are important markers in determining subclinical inflammation, systemic inflammation, and prognosis of some diseases. 4 Thus, all confounding factors should be considered and detailed standardized methods must be used in determining NLR and PLR.…”

mentioning

confidence: 99%

The ratio Neutrophil/Lymphocyte and Platelet/Lymphocyte in patient with Rheumatoid Arthritis that are Treating with Anti-TNF

Cited by 44 publications

References 17 publications

The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in patients with rheumatoid arthritis

Assessment of Neutrophil- Lymphocyte and Platelet- Lymphocyte Ratios in Ankylosing Spondylitis

Contact Info

Product

Resources

About