The Ratio of CD86+/CD163+ Macrophages Predicts Postoperative Recurrence in Stage II-III Colorectal Cancer

Xu, Guozeng; Jiang, Lei; Cheng, Yufeng; Qin, Guizhen; Luo, Zuojie; Mo, Yuzhen; Chen, Jian

doi:10.3389/fimmu.2021.724429

Cited by 12 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of previous studies suggest that age, TNM stage, pathological tumour grading, and CEA all in uence the prognosis of CRC patients [10][11][12] , which is in agreement with the ndings in this study that patients characterized by age ≤ 65 years, TNM stage I-II, pathological high/moderate differentiation, and CEA < 5 µg/L had a longer OS. This study nally revealed that AAPR is a new effective predictor of postoperative prognosis in CRC patients (its AUC = 0.730 for ROC is greater than the AUC = 0.659 for TNM staging ROC).…”

Section: Discussionsupporting

confidence: 93%

The influence of the preoperative albumin to alkaline phosphatase ratio on OS in postradical colorectal cancer and the construction of a nomogram prediction model

Jiang

Feng

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective The albumin to alkaline phosphatase ratio (AAPR) is a newly developed blood biomarker that has been reported to have prognostic value in several types of cancers. The aim of this study was to investigate the predictive value of AAPR in overall survival after radical colon cancer surgery in patients with stage I-III colorectal cancer (CRC). Methods The clinical data of 221 eligible patients with stage I ~ III CRC were retrospectively analysed. A series of survival analyses were performed to assess the prognostic value of AAPR. Univariate and multifactorial Cox analyses were performed to identify independent risk factors. Columnar graph prediction models were further constructed based on independent risk factors such as AAPR, and their predictive properties were validated. Results The optimal cutoff value of preoperative AAPR for postoperative OS in patients undergoing laparoscopic radical CRC was 0.495 as shown by univariate and multifactorial Cox regression analysis. The factors of age ≤ 65 years, TNM stage I-II, tumour grading (high/medium differentiation), CEA ≤ 5 and AAPR ≥ 0.495 were associated with better OS (P < 0.05). Conclusions Preoperative AAPR level was a good predictor of postoperative survival in patients undergoing laparoscopic radical CRC surgery, and AAPR < 0.495 was an independent risk factor for decreased postoperative OS.

show abstract

Section: Discussionsupporting

confidence: 93%

The influence of the preoperative albumin to alkaline phosphatase ratio on OS in postradical colorectal cancer and the construction of a nomogram prediction model

Jiang

Feng

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Subsequently, univariate and multifactorial analyses were performed, and survival curves for 5-year OS were plotted. The results of previous studies suggest that age, TNM stage, pathological tumor grading, and CEA all influence the prognosis of CRC patients, [10][11][12] which is in agreement with the findings in this study that patients characterized by age ≤65 years, TNM stage I-II, pathological high/moderate differentiation, and CEA <5 μg/L had a longer OS. This study finally revealed that AAPR is a new effective predictor of postoperative prognosis in CRC patients (its AUC = .730 for ROC is greater than the AUC = .659 for TNM staging ROC).…”

Section: Discussionsupporting

confidence: 92%

The Influence of the Preoperative Albumin to Alkaline Phosphatase Ratio on Overall Survival in Post-Radical Surgery for Colorectal Cancer and the Construction of a Nomogram Prediction Model

Jiang,

Xun,

et al. 2023

The American Surgeon™

View full text Add to dashboard Cite

Purpose The albumin to alkaline phosphatase ratio (AAPR) is a newly developed blood biomarker that has been reported to have prognostic value in several types of cancers. The aim of this study was to investigate the predictive value of AAPR in overall survival after radical colon cancer surgery in patients with stage I-III colorectal cancer (CRC). Methods The clinical data of 221 eligible patients with stage I ∼ III CRC were retrospectively analyzed. A series of survival analyses were performed to assess the prognostic value of AAPR. Univariate and multifactorial Cox analyses were performed to identify independent risk factors. Columnar graph prediction models were further constructed based on independent risk factors such as AAPR, and their predictive properties were validated. Results The optimal cutoff value of preoperative AAPR for postoperative overall survival (OS) in patients undergoing laparoscopic radical CRC was .495 as shown by univariate and multifactorial Cox regression analysis. The factors of age ≤65 years, Tumor-Node-Metastasis (TNM) stage I-II, tumor grading (high/medium differentiation), CEA ≤5, and AAPR ≥.495 were associated with better OS ( P < .05). Conclusions Preoperative AAPR level was a good predictor of postoperative survival in patients undergoing laparoscopic radical CRC surgery, and AAPR <.495 was an independent risk factor for decreased postoperative OS.

show abstract

“…The baseline demographic and clinical characteristics were comprehensively evaluated and compared according to disease severity (with progression versus without progression) and survival outcome (survival versus death). The optimal cutoff value for continuous variables was calculated using the Maxstat algorithm [ 12 ]. Categorical variables were compared according to chi-squared test or Fisher’s exact test.…”

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics, Course, and Long-Term Outcomes in Patients with Talaromyces marneffei Infection: A 10-Year Retrospective Cohort Study

Wei

Xiao

et al. 2023

Infect Dis Ther

View full text Add to dashboard Cite

Introduction Talaromyces marneffei ( T . marneffei ), a dimorphic fungus, causes local or disseminated infection in humans. We aimed to analyze the clinical characteristics, prognostic factors, and survival outcomes of patients with T . marneffei infection and compare the differences between human immunodeficiency virus (HIV)-positive and HIV-negative subgroups. Methods We retrospectively analyzed 241 patients with T . marneffei infection at the First Affiliated Hospital of Guangxi Medical University between January 2012 and January 2022. The overall population was stratified into HIV-positive ( n = 98) and HIV-negative ( n = 143) groups according to HIV status. Kaplan–Meier analysis and multivariate Cox regression models were used to determine the prognostic factors for overall survival (OS) and progression-free survival (PFS). Results With a median follow-up time of 58.9 months, 120 patients (49.8%) experienced disease progression and 85 patients (70.8%) died. The 5-year rates of OS and PFS were 61.4% (95% CI 55.0–68.6%) and 47.8% (95% CI 41.5–55.1%), respectively. As an independent factor, patients who were HIV positive had better PFS (HR 0.50, 95% CI 0.31–0.82; p < 0.01) than patients who were HIV negative. Compared with patients who were HIV positive, patients who were HIV negative were older and had more probabilities of underlying diseases, chest involvement, bone destruction, and higher count of neutrophils (all p < 0.05). Hemoglobin (PFS: HR 0.62; 95% CI 0.39–1.00; p < 0.05; OS: HR 0.45; 95% CI 0.22–0.89; p = 0.02) and lymphocyte count (PFS: HR 0.06; 95% CI 0.01–0.26; p < 0.01; OS: HR 0.08; 95% CI 0.01–0.40; p < 0.01) were independent prognostic factors for PFS and OS in patients who were HIV negative. Conclusions Patients with T . marneffei infection have a poor prognosis. Patients who are HIV positive and HIV negative have relatively independent clinical characteristics. Multiple organ involvement and disease progression are more common in patients who are HIV negative. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-023-00801-5.

show abstract

The Ratio of CD86+/CD163+ Macrophages Predicts Postoperative Recurrence in Stage II-III Colorectal Cancer

Cited by 12 publications

References 36 publications

The influence of the preoperative albumin to alkaline phosphatase ratio on OS in postradical colorectal cancer and the construction of a nomogram prediction model

The influence of the preoperative albumin to alkaline phosphatase ratio on OS in postradical colorectal cancer and the construction of a nomogram prediction model

The Influence of the Preoperative Albumin to Alkaline Phosphatase Ratio on Overall Survival in Post-Radical Surgery for Colorectal Cancer and the Construction of a Nomogram Prediction Model

Clinical Characteristics, Course, and Long-Term Outcomes in Patients with Talaromyces marneffei Infection: A 10-Year Retrospective Cohort Study

Contact Info

Product

Resources

About