The ratio of cytotoxic lymphocytes to M2-like macrophages is prognostic in immunogenic tumors

Abstract

Immune cells in the microenvironment shape tumor development and progression. The prognostic value of T-cell-based immune scores exceeds those of clinical parameters in colon cancer, but reflects only a part of the anti-tumor immune response. Here, we assessed 15 distinct immune cell classes and identified a simple prognostic signature based on pro- and anti-tumoral immune cells in the tumor microenvironment. The ratio of cytotoxic lymphocytes to tumor supportive macrophages predicted survival better than the state-of-art immune score in colon cancer and had the highest relative contribution to survival prediction when compared to established clinical parameters. This signature was prognostic also in other cancers with high mutation burden, such as those of the lung, bladder, esophagus, and melanomas, supporting broad clinical applicability.

The effect of exercise and disease status on mobilization of anti-tumorigenic and pro-tumorigenic immune cells in women with breast cancer

“…Tumor immune surveillance is a balance between immune cells that promote tumor progression (pro-tumorigenic cells) and cells that promote tumor rejection (anti-tumorigenic cells) (4). Studies in animal cancer models have shown that exercise shrinks tumors by enhancing the tumor infiltration of anti-tumorigenic cells, thus natural killer (NK) and cytotoxic T cells (5,6).…”