The ratio of insulin, sex hormones, sex hormone-binding β-globulin, parameters of lipid metabolism and glucose in the male population of the Arctic

Бичкаева, Ф. А.; Типисова, Е. В.; Volkova, Natalya

doi:10.17116/repro201622299-110

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…Характерное для коренных жителей Севера повышение антиатерогенной защиты организма за счет увеличения уровня ХС ЛПВП и снижения содержания ХС ЛПОНП и ХС ЛПНП наиболее сохранено у кочующих аборигенов [14,15]. У оседлых коренных жителей вследствие изменения структуры питания, гиподинамии и развития АО такая защита значительно снижается.…”

Section: Discussionunclassified

“…У оседлых коренных жителей вследствие изменения структуры питания, гиподинамии и развития АО такая защита значительно снижается. Многие авторы связывают это и с нарушением липидного обмена на фоне гипоандрогении у мужчин [14] и гипоэстрогенемии у женщин [16].…”

Section: Discussionunclassified

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Clinical variants of the metabolic syndrome in young people living in the Khanty-Mansiysk autonomous region – Yugra

Korneeva,

Voevoda

2024

Sibirskij nauchnyj medicinskij zhurnal

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Currently the “rejuvenation” and an increase in the number of components of the metabolic syndrome (MS) determine its clinical significance in the earlier development of diabetes mellitus, cardiovascular diseases and related complications. Aim of the study was to investigate the features of the MS clinic picture in a population of young men and womenliving in the Khanty-Mansiysk autonomous region – Yugra.Material and methods. The study included 863 young people between 18 and 44 years of age, including 344 men and women with MS and 519 people in the comparison group. Studied subgroups are represented by non-indigenous men and women living in urban and rural areas, and indigenous rural residents. The analysis of MS clinical and laboratory parameters was carried out and its clinical variants in ethnic groups were identified.Results and its discussion. According to the results of the survey of young people with metabolic syndrome, it was revealed that the combination of abdominal obesity and two components of MS were most common in young people with MS (in 50.0 % men and in 55.5 % women). The study defined regression models for each MS group and threshold values for waist circumference were set, which changes in lipid and carbohydrate metabolism were predicted.Conclusions. In groups with MS, hypertriglyceridemia was determined as its most common component. The study identified the most frequent association of abdominal obesity with hyper-LDL cholesterol and hypertriglyceridemia in patients with metabolic syndrome, in ethnic groups, this combination is more common in indigenous rural men (53.3 %) and in non-indigenous urban women (54.3 %).

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Section: Discussionunclassified

Clinical variants of the metabolic syndrome in young people living in the Khanty-Mansiysk autonomous region – Yugra

Korneeva,

Voevoda

2024

Sibirskij nauchnyj medicinskij zhurnal

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“…Однако в современных реалиях при изменении качественной структуры питания, снижении двигательной активности можно говорить об истощении резервных возможностей печени и как следствие -о нарастании в крови концентрации СЖК, триглицеридов, холестерина и атерогенных фракций липидов [27], а поскольку печень является ещё и органом-мишенью, атерогенная дислипидемия может выразиться в развитии НАЖБП. Нами не проводились инструментальные исследования печени, но тем не менее обследованный контингент пожилого возраста можно отнести к группе риска развития жирового гепатоза -начальной стадии НАЖБП -вследствие значимого повышения концентрации глюкозы, а также выявленного нами нарастания концентраций жирных кислот, величин ИМТ [28] на фоне возрастного истощения функциональной и рецепторной активности β-клеток поджелудочной железы и формирования инсулинорезистентности [29], несмотря на отсутствие значимого увеличения активности трансаминаз. Ведь начальные стадии гепатоза могут долгое время протекать без клинических изменений показателей крови, и первичными звеньями патогенеза этого заболевания выступают ожирение и сопряжённое с ним избыточное накопление СЖК и триглицеридов в печени, а также инсулинорезистентность, зачастую независимо от ожирения создающая предпосылки для повреждения печени [4].…”

Section: Discussionunclassified

Age-related changes in the glucose level, its metabolites, and aminotransferases activity in women and men of mature and elderly age

Бичкаева

Власова

Shengof

et al. 2022

Ekologiya cheloveka (Human Ecology)

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Introduction: Adaptation to living conditions in the North in humans is determined by its energy status, in particular glucose homeostasis, and the activity of a number of enzymes - aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Aim: To conduct a comparative analysis of the levels of glucose, lactate, pyruvate, activity of AST, ALT, their ratio of different age groups in men and women - residents of the subarctic region of the Arkhangelsk Region. Methods. The article is an observational cross-sectional uncontrolled study, where differences in the content of carbohydrate metabolism parameters and transferase activity between groups of women and men of different age periods are considered. 437 women and 194 men aged 21-74 years, born and permanently residing in the Arkhangelsk region, were examined. In the blood serum, the glucose content was determined by the enzymatic method, the lactate level was measured by the Trinder reaction, the pyruvate level - by the Umbright method, the activity of AST and ALT - by the unified kinetic method, and the values of the AST/ALT ratio (De Ritis ratio) were calculated. The study participants were divided into 4 age groups: women 21-35, 36-45, 46-55, 56-74 years, men 22-35, 36-45, 46-60 and 61-74 years. Results: Non-parametric comparison showed an age-related increase in blood glucose in women aged 46-55 years with an increase in the activity of AST, ALT, in men aged 61-74 years with a decrease in ALT, which indicates different mechanisms for its increase; an increase in the number of people with a critical glucose level (prediabetes - 5.6-6.1 mmol / l and above normal) in older age groups can serve as confirmation of the onset of hyperglycemia and be the cause and / or consequence of the insulin resistance. An individual analysis of the De Ritis ratio revealed individuals with different metabolic flows in glucose homeostasis in all gender and age groups. With age in 57.5; 66.7; 59.5 and 52.4% of women and in 72.6; 63.2; 74.1 and 28.6% of men there was predominated anabolic processes, which, with an increase in glucose, increases the risk of insulin resistance. Conclusions: The shown features of the state of carbohydrate metabolism and aminotransferases in men and women, taking into account age, can contribute to diagnostic and preventive measures to preserve health among the population of the Arctic.

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The ratio of insulin, sex hormones, sex hormone-binding β-globulin, parameters of lipid metabolism and glucose in the male population of the Arctic

Cited by 2 publications

References 14 publications

Clinical variants of the metabolic syndrome in young people living in the Khanty-Mansiysk autonomous region – Yugra

Clinical variants of the metabolic syndrome in young people living in the Khanty-Mansiysk autonomous region – Yugra

Age-related changes in the glucose level, its metabolites, and aminotransferases activity in women and men of mature and elderly age

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