The Ratio of NT-proBNP to CysC1.53 Predicts Heart Failure in Patients With Chronic Kidney Disease

Wang, Sheng; Li, Ming; Wang, Xiangyu; Luo, Jing; Zou, Yulin; Hu, Yang; Liu, Xingtai; Ao, Hua; Yao, Xueer; Li, Chufeng; Yang, Tingting

doi:10.3389/fcvm.2021.731864

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…As a common type of cardiovascular disease in clinical practice, the incidence of chronic HF [7][8][9] usually increases with the increase of age, and it is also one of the important causes of cardiovascular disease death in the elderly, seriously threatening people's life and health [10]. According to clinical studies, the pathological features of chronic HF are usually reflected in neuroendocrine disorders, myocardial remodeling, increased preload, and so on [11].…”

Section: Related Workmentioning

confidence: 99%

[Retracted] Analysis of the Application Value of Echocardiography Combined with CK‐MB, Alb, and CysC in the Prognosis Assessment of Patients with Chronic HF

Zhu

Chen

et al. 2022

Contrast Media & Molecular Imaging

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In order to evaluate the diagnostic and prognostic value of echocardiography combined with serum creatine kinase-MB (CK-MB), albumin (Alb), and cystatin C (CysC) in patients with chronic heart failure (HF), 93 patients diagnosed with chronic HF in our hospital from March 2019 to January 2020 are retrospectively analyzed and included in the HF group. Another 100 healthy subjects who come to our hospital for general physical examination are selected as the control group. Echocardiography is used to detect the cardiac parameters of each group. The experimental results show that echocardiography parameters combined with CK-MB, Alb, and CysC have high application value in diagnosis and evaluation of patients with chronic HF, which can provide theoretical basis for improving the prognosis of patients with chronic HF through real-time monitoring of the above indicators.

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Section: Related Workmentioning

confidence: 99%

[Retracted] Analysis of the Application Value of Echocardiography Combined with CK‐MB, Alb, and CysC in the Prognosis Assessment of Patients with Chronic HF

Zhu

Chen

et al. 2022

Contrast Media & Molecular Imaging

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“…Для решения вопроса определения риска развития ХСН при ХБП Wang S, et al (2021) предложили дополнительные предикторы, которые также связаны с определением цистатина С в крови [18]. Исследователи показали, что соотношение NT-proBNP к цистатину С 1,53 , равное 847,964, явилось независимым ФР кардиальной дисфункции при ХБП.…”

Section: Discussionunclassified

Risk of heart failure depending on the state of renal filtration function in patients with uncomplicated hypertension

Chernyavina

Козиолова

2022

Russ J Cardiol

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Aim. To assess the risk of heart failure (HF) depending on the state of renal filtration function in patients with uncomplicated hypertension (HTN) without kidney dysfunction.Material and methods. This cross-sectional screening clinical trial consecutively included 176 outpatients with uncomplicated HTN and without chronic kidney disease (CKD). To assess the HF risk, the blood concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) was determined. To assess the renal filtration function, the blood serum concentration of creatinine and cystatin C was determined, followed by glomerular filtration rate (GFR) estimation using the CKDEPI equation with both parameters. Echocardiography was performed to assess the cardiac structural and functional state.Results. Correlation analysis revealed a moderate direct relationship between NT-proBNP and blood cystatin C concentration (r=0,370; p<0,005), as well as a moderate inverse relationship with GFR (CKD-EPIcre) and GFR (CKD-EPIcys) (r= -0,321; p<0,05 and r=-0,360; p<0,005, respectively). ROC curve for all available values of blood cystatin C revealed the most optimal cut-off threshold of 1016 ng/ml (AUC=0,726, p<0,001), which ensures the sensitivity of 72,2% (p<0,001) and specificity of 62,0% (p<0,001). ROC curve for all available GFR values (CKD-EPIcys) revealed a cut-off threshold of 74 ml/min/1,73 m2 (AUC=0,702, p=0,002) with a sensitivity and specificity of 55,6% and 74,7%, respectively (p=0,001 and p=0,001, respectively). Taking into account the cut-off points for cystatin C and GFRcys, the first group consisted of 73 (41,48%) patients with cystatin C ≥1016 ng/ml and GFR (CKD-EPIcys) ≤74 ml/min/1,73 m2, while the second one — 103 (58,52%) patients with cystatin C <1016 pg/ml and GFR (CKDEPIcys) >74 ml/min/1,73 m2. The presence of impaired glucose tolerance, left ventricular diastolic dysfunction (LV DD), LV hypertrophy and left atrial enlargement leads to an additional increase in HF risk in patients with uncomplicated HNT without CKD.Conclusion. The ROC analysis showed that cystatin C and cystatin C-based GFR (CKD-EPIcys) can be used as markers of HF risk in patients with uncomplicated HTN without CKD. With an increase in cystatin C ≥1016 ng/ml, the relative risk of HF is 2,99, while with a decrease in GFR (CKD-EPIcys) ≤74 ml/min/1,73 m2 — 1,26. The presence of impaired glucose tolerance, LV DD, LV hypertrophy and left atrial enlargement in patients with uncomplicated HTN without CKD with a cystatin C increase ≥1016 ng/ml and a decrease in GFR (CKD-EPIcys) ≤74 ml/min/1,73 m2 and below further increases the risk of developing CHF.

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“…4-point MACE (4-P MACE) : Composite of cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke and hospitalization for heart failure. Given the lack of accepted definition for heart failure in CKD population, we defined “hospitalization for heart failure” as symptoms of heart failure along with elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (> 1200 pg/dL) requiring hospitalization and intravenous diuretic therapy and/or ultrafiltration for the purpose of this study [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

A comparative analysis of conventional and speckle-tracking strain echocardiographic findings in diabetic and non-diabetic kidney disease patients with normal ejection fraction

Paramasivam

Rao

Samanth

et al. 2022

Int J Cardiovasc Imaging

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This study aimed to compare the differences in echocardiographic and strain parameters in patients with diabetic kidney disease (DKD) and non-diabetic kidney disease (NDKD) in a cohort with pre-dialysis chronic kidney disease (CKD) and normal ejection fraction (EF). In this single-center prospective study, patients with CKD stages 3–5 and EF > 55% were included. We compared cardiac structure and function using conventional and speckle-tracking strain echocardiography among DKD and NDKD groups. Cardiovascular outcomes were assessed at the end of the study. Of the included 117 patients, 56 (47.9%) had DKD, and 61 (52.1%) had NDKD. Patients with DKD had higher ratios of early mitral inflow velocity and mitral annular early diastolic velocity (E/e’) (11.9 ± 4.4 vs. 9.8 ± 3.5; p = 0.004), lower septal e’ velocity (7.1 ± 2.5 vs. 8.2 ± 2.8; p = 0.031), lower lateral e’ velocity (9.2 ± 2.9 vs. 10.4 ± 3.8; p = 0.045) and longer deceleration times (209.2 ± 41.5 vs. 189.1 ± 48.0; p = 0.017), compared to those with NDKD. Left ventricular mass index (LVMI), global longitudinal strain (GLS), early diastolic strain rate (SRE), and E/SRE were similar. At a median follow-up of 239 days, 3-P MACE (11.5% vs. 4.9%; p = 0.047) and 4-P MACE (28.6% vs. 11.5%; p = 0.020) were observed to be higher in the DKD group. Diastolic dysfunction was more common in patients with DKD, compared to those with NDKD, although both groups had similar LVMI and GLS. Those with DKD also had poorer cardiovascular outcomes. This highlights the importance of the assessment of diastolic function in CKD, particularly in those with diabetic CKD.

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The Ratio of NT-proBNP to CysC1.53 Predicts Heart Failure in Patients With Chronic Kidney Disease

Cited by 6 publications

References 30 publications

[Retracted] Analysis of the Application Value of Echocardiography Combined with CK‐MB, Alb, and CysC in the Prognosis Assessment of Patients with Chronic HF

[Retracted] Analysis of the Application Value of Echocardiography Combined with CK‐MB, Alb, and CysC in the Prognosis Assessment of Patients with Chronic HF

Risk of heart failure depending on the state of renal filtration function in patients with uncomplicated hypertension

A comparative analysis of conventional and speckle-tracking strain echocardiographic findings in diabetic and non-diabetic kidney disease patients with normal ejection fraction

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