The ratio of plasma to whole-blood serotonin may be a novel marker of atherosclerotic cardiovascular disease

Hara, Kuniko; Hirowatari, Yuji; Yoshika, Masamichi; Komiyama, Yutaka; Tsuka, Yoshiaki; Takahashi, Hakuo

doi:10.1016/j.lab.2004.03.014

Cited by 62 publications

(51 citation statements)

References 25 publications

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“…It has been reported that serotonin released into the coronary circulation following PCI causes an increase in vascular tone with a significant decrease in the regional blood flow 24) . Atherosclerotic vulnerable plaques, such as intense yellow plaques, may more easily release serotonin in comparison to non-intense yellow plaques 25) . In this study, flow complications might have been only transient slow flow, and persistent slow-flow and no-reflow phenomena were not identified in any cases.…”

Section: Discussionmentioning

confidence: 99%

Intense Yellow Culprit Plaque Coloration is Closely Associated with Troponin-T Elevation and Flow Complications Following Elective Coronary Stenting

Murakami

Takano

Yamamoto

et al. 2011

JAT

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Section: Discussionmentioning

confidence: 99%

Intense Yellow Culprit Plaque Coloration is Closely Associated with Troponin-T Elevation and Flow Complications Following Elective Coronary Stenting

Murakami

Takano

Yamamoto

et al. 2011

JAT

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“…A variety of methods have been developed to measure serotonin including spectrophotometry [21,22], LCfluorometry [23,24], enzyme immunoassay, and LCelectrochemical detection [25,26]. LC-mass spectrometric methods is however the method of choice as tandem LC-MS methods provide increased selectivity while reducing the need for dependence on chromatographic separation [27][28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Development of an LC-MS/MS method for the analysis of serotonin and related compounds in urine and the identification of a potential biomarker for attention deficit hyperactivity/hyperkinetic disorder

et al. 2011

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Serotonin is a major neurotransmitter and affects various functions both in the brain and in the rest of the body. It has been demonstrated that altered serotinergic function is implicated in various psychiatric disorders including depression and schizophrenia. Serotonin has also been implicated along with dopamine in attention deficithyperkinetic disorder (AD-HKD). This study provides a versatile validated method for the analysis of serotonin, hydroxyindole acetic acid and dopamine in urine using LC-MS/MS. This method was then used to quantify these analytes in a test group of 17 children diagnosed with severe AD-HKD. This group was compared to a matched control group to investigate the possibility that one of these compounds may be a potential biomarker for this condition. The developed method provided good linear calibration curves for the multiplex assay of analytes in urine (0.05-3.27 nmol/L; R 2 ≥0.9977). Acceptable inter-day repeatability was achieved for all analytes with RSD values (n=9) ranging from 1.1% to 9.3% over a concentration range of 0.11-3.27 μmol/L in urine. Excellent limits of detection (LOD) and limits of quantitation (LOQ) were achieved with LODs of 8.8-18.2 nmol/L and the LOQs of 29.4-55.7 nmol/L for analytes in urine. Recoveries were in the ranges of 98-104%, 100-106% and 91-107% for serotonin, 5-HIAA and dopamine, respectively. An appropriate sample clean-up procedure for urine was developed to ensure efficient recovery and reproducibility on analysis. Evaluation of matrix effects was also carried out and the influence of ion suppression on analytical results reported. Confirmatory analysis was carried out on a linear trap quadrupole-Orbitrap mass spectrometer to obtain high mass accuracy data of the target analytes in the clinical samples.

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“…Serotonin also acts as a growth factor stimulating mitogenesis and migration of arterial smooth muscle cells 31 . Recent studies propose that serotonin is useful as a novel marker for atherosclerotic vascular disease [32][33][34] .…”

Section: Discussionmentioning

confidence: 99%

Ativação plaquetária em formas clínicas distintas da doença arterial coronariana (papel da P-selectina e de outros marcadores nas anginas estável e instável)

Venturinelli¹,

Hovnan²,

Soeiro³

et al. 2006

Arq. Bras. Cardiol.

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objective: Markers of platelet activation are elevated in coronary artery disease. We sought to identify the presence and the potential associations of different markers of platelet activation. Methods:We studied patients with unstable angina (n=28), patients with stable angina (n=36) and patients without coronary artery disease (n=30); sex and age matched. Blood levels of the adhesion molecule P-selectin, Thromboxane B2 and Serotonin were measured by enzyme immunoassays.results: When we compared the groups the results were: sP-selectin, thromboxane B2 and serotonin levels were significantly higher in patients with unstable angina than in patients with stable angina.conclusion: These markers of platelet activation were able to identify unstable forms of coronary artery disease.

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The ratio of plasma to whole-blood serotonin may be a novel marker of atherosclerotic cardiovascular disease

Cited by 62 publications

References 25 publications

Intense Yellow Culprit Plaque Coloration is Closely Associated with Troponin-T Elevation and Flow Complications Following Elective Coronary Stenting

Intense Yellow Culprit Plaque Coloration is Closely Associated with Troponin-T Elevation and Flow Complications Following Elective Coronary Stenting

Development of an LC-MS/MS method for the analysis of serotonin and related compounds in urine and the identification of a potential biomarker for attention deficit hyperactivity/hyperkinetic disorder

Ativação plaquetária em formas clínicas distintas da doença arterial coronariana (papel da P-selectina e de outros marcadores nas anginas estável e instável)

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