The rationale and design of a Mediterranean diet accompanied by time restricted feeding to optimise the management of type 2 diabetes: The MedDietFast randomised controlled trial

Papamichou, Dimitra; Panagiotakos, Demosthenes B.; Holmes, Elaine; Koutsakis, P.; Katsoulotos, Hariklia; Loo, Ruey Leng; Itsiopoulos, Catherine

doi:10.1016/j.numecd.2021.09.031

Cited by 6 publications

(3 citation statements)

References 56 publications

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“…In addition, the MD exerts antioxidant and anti-hyperglycemic effects by augmenting GLP-1 activity in endothelial cells. These findings are also supported by two recent human studies showing that MD adherence over 210 days or 24 weeks was associated with lower serum glucose, elevated fasting GLP-1 level, and improved insulin resistance and HgbA1c [ 94 , 95 ]. Importantly, some of the bacterial genera changes associated with the MD, such as decreases in Prevotella and Bacteroides, may influence markers of insulin resistance [ 96 ].…”

Section: Influence Of Nutrition In Modulating Gut Microbiota and Mark...supporting

confidence: 73%

“…One large-scale observational study of over 22,000 human participants who adhered to the MD for 6 months showed that these individuals had a lower risk of new onset T2DM [ 92 ]. The mechanisms behind improvements in glucose homeostasis include a reduction in inflammatory processes [ 93 ], the modulation of gut hormones [ 94 , 95 ], and altered production of microbial metabolites [ 96 ]. For example, 12-week adherence to the MD reduced pro-inflammatory cytokine interleukin-6 (IL-6) by 49% in T2DM patients [ 93 ].…”

Section: Influence Of Nutrition In Modulating Gut Microbiota and Mark...mentioning

confidence: 99%

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Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

Hamamah,

Iatcu,

Covasa

2024

Nutrients

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Nutrition is one of the most influential environmental factors in both taxonomical shifts in gut microbiota as well as in the development of type 2 diabetes mellitus (T2DM). Emerging evidence has shown that the effects of nutrition on both these parameters is not mutually exclusive and that changes in gut microbiota and related metabolites such as short-chain fatty acids (SCFAs) and branched-chain amino acids (BCAAs) may influence systemic inflammation and signaling pathways that contribute to pathophysiological processes associated with T2DM. With this background, our review highlights the effects of macronutrients, carbohydrates, proteins, and lipids, as well as micronutrients, vitamins, and minerals, on T2DM, specifically through their alterations in gut microbiota and the metabolites they produce. Additionally, we describe the influences of common food groups, which incorporate varying combinations of these macronutrients and micronutrients, on both microbiota and metabolic parameters in the context of diabetes mellitus. Overall, nutrition is one of the first line modifiable therapies in the management of T2DM and a better understanding of the mechanisms by which gut microbiota influence its pathophysiology provides opportunities for optimizing dietary interventions.

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Section: Influence Of Nutrition In Modulating Gut Microbiota and Mark...supporting

confidence: 73%

Section: Influence Of Nutrition In Modulating Gut Microbiota and Mark...mentioning

confidence: 99%

Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

Hamamah,

Iatcu,

Covasa

2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Due to its antioxidant effects and anti-hyperglycemic effects, the MD enhances GLP-1 action in endothelial cells as well as improving endothelial function in general as measured through flow-mediated dilatation in the brachial artery. Two recent studies have supported these findings with one reporting that obese T2DM human subjects following the MD for 210 days exhibited statistically significant elevations in fasting GLP-1 levels with lower serum glucose [167], and with the other showing similar increases in GLP-1 and improved insulin sensitivity [168]. Taken together, these findings suggest that the MD can support sustained changes in gut microbiota such as normalizing the amounts of Bacteroides and Prevotella copri and metabolites like BCAA to improve insulin resistance, thereby enhancing GLP-1 secretion and promoting weight loss.…”

Section: Mediterranean Dietmentioning

confidence: 81%

Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake

Hamamah,

Amin,

Al-Kassir

et al. 2023

Nutrients

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Obesity is a multifactorial disease that continues to increase in prevalence worldwide. Emerging evidence has shown that the development of obesity may be influenced by taxonomic shifts in gut microbiota in response to the consumption of dietary fats. Further, these alterations in gut microbiota have been shown to promote important changes in satiation signals including gut hormones (leptin, ghrelin, GLP-1, peptide YY and CCK) and orexigenic and anorexigenic neuropeptides (AgRP, NPY, POMC, CART) that influence hyperphagia and therefore obesity. In this review, we highlight mechanisms by which gut microbiota can influence these satiation signals both locally in the gastrointestinal tract and via microbiota-gut-brain communication. Then, we describe the effects of dietary interventions and associated changes in gut microbiota on satiety signals through microbiota-dependent mechanisms. Lastly, we present microbiota optimizing therapies including prebiotics, probiotics, synbiotics and weight loss surgery that can help restore beneficial gut microbiota by enhancing satiety signals to reduce hyperphagia and subsequent obesity. Overall, a better understanding of the mechanisms by which dietary fats induce taxonomical shifts in gut microbiota and their impact on satiation signaling pathways will help develop more targeted therapeutic interventions in delaying the onset of obesity and in furthering its treatment.

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A Chinese medical nutrition therapy diet accompanied by intermittent energy restriction alleviates type 2 diabetes by enhancing pancreatic islet function and regulating gut microbiota composition

Luo

Zhou

Yang

et al. 2022

Food Research International

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The rationale and design of a Mediterranean diet accompanied by time restricted feeding to optimise the management of type 2 diabetes: The MedDietFast randomised controlled trial

Cited by 6 publications

References 56 publications

Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake

A Chinese medical nutrition therapy diet accompanied by intermittent energy restriction alleviates type 2 diabetes by enhancing pancreatic islet function and regulating gut microbiota composition

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