2012
DOI: 10.1097/iae.0b013e318241ae55
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The Rationale of Retinal Endovascular Fibrinolysis in the Treatment of Retinal Vein Occlusion

Abstract: Retinal endovascular fibrinolysis constitutes an efficient method of micropuncture and reperfusion of an experimentally occluded retinal vein. Thrombus formation at the punctured site can be prevented by injection of tissue plasminogen activator.

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Cited by 13 publications
(16 citation statements)
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“…This is in contrast to the findings of Pournaras et al. () who reported haemorrhages but only with larger needle tip diameters. Noteworthy is that there were no haemorrhages after a cannulation at the optic disc border.…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…This is in contrast to the findings of Pournaras et al. () who reported haemorrhages but only with larger needle tip diameters. Noteworthy is that there were no haemorrhages after a cannulation at the optic disc border.…”
Section: Discussioncontrasting
confidence: 99%
“…A glass microneedle was developed following the specifications described by Pournaras et al. (). The 500‐ μ m‐long tip has an outer diameter of 30 μ m and is angulated 30° with respect to the shaft (Fig.…”
Section: Methodsmentioning
confidence: 99%
“…Thus, the search for better therapeutic approaches continues. Emerging treatment modalities can be divided into those aimed to resolve the obstruction of venous outflow (endovascular fibrinolysis [105,106,107], endovascular cannulation [108], and systemic thrombolytics [109]) and those aimed at the sequelae of RVO (macular edema and macular ischemia). Therapies aimed at the latter can be grouped into those that minimize reperfusion injury [110], provide hemodilution [111], modify retinal vascular permeability [112], and offer neuroprotection [113] and pharmacologic vitreolysis [113,114,115,116,117].…”
Section: Emerging Therapiesmentioning
confidence: 99%
“…Conversely, others believe that acetylsalicylic acid increases optic nerve head blood flow and leads to more rapid resolution of macular oedema associated with non‐ischaemic central RVO . Retinal endovascular fibrinolysis, the direct injection of tissue plasminogen activator into an occluded central retinal vein post‐vitrectomy with or without ancillary intravitreal steroid or scatter laser, promotes visual recovery superior to natural history, while mitigating the potential side effects of systemic tissue plasminogen activator . Prompt administration of treatment prior to thrombus organisation appears to improve success …”
Section: Treatmentmentioning
confidence: 99%