The re‐synthesis of creatinephosphoric acid in frog's muscle poisoned with iodoacetic acid

Abstract

In the case of aerobic muscle it was shown by M eyerhof and Boyland [1931] that muscle poisoned with iodoacetate had a respiratory quotient of 0 7, which was restored to a normal value of 0 95 by addition to the system of sodium d-lactate. This discovery led to the observation by Mawson [1932] that if sodium d-lactate was supplied to a muscle which was subsequently poisoned with iodoacetate the muscle would, in the presence of the lactate and oxygen, give a much longer series of twitches than would a poisoned muscle in presence of oxygen alone. It was shown that this prevention of the development of the symptoms of iodoacetate poisoning depended upon the presence of oxygen, and that