THE REACTION OF 2,4-BIS(4-METHOXYPHENYL)-l,3,2,4-D1THIA DIPHOSPHETANE-2,4-DISULFIDE (LR) WITH COUMARIN OXIME AND HYDRAZONE DERIVATIVES. SYNTHESIS OF BENZOPYRANO (3,2-D)-Δ⁵-2,1,3-OXAZA- AND 1,2,3-DIAZA-PHOSPHOLINES

Studies on Organophosphorus Compounds. Part 1: Synthesis and In Vitro Antimicrobial Activity of Some New Pyrimido[5′,4′:5,6]pyrano[2,3‐d][1,3,2]thiazaphosphinine Compounds

“…Lawesson's reagent (LR) is the most effective and versatile thiation reagent for carbonyl compounds . Also LR undergoes ring closure reactions with substrates containing two functional groups , forming phosphorus heterocycles that have tremendous biological activities such as insecticidal , antibacterial, and antifungal effects and which are anticancer pharmacophores . Based on these concepts and further to our studies on the synthesis of bioactive molecules , we have started to synthesize and investigate the biological activities of new fused P‐heterocycles via reaction of LR with pyrano[2,3‐ d ]pyrimidine‐2,4‐(1 H ,3 H )‐diones.…”