The reaction of (2-oxo-2-phenyl-ethyl sulfanyl)-Acetic Acid with Chalcones: Double Michael Addition-Aldol Reaction Formation of Unexpected (5-Benzoyl-2-hydroxy-2,4-6-triphenyl-cyclohexyl) -phenyl-methanone

Abstract

A greener approach one-pot reaction of (2-oxo-2-phenyl-ethyl sulfanyl)-acetic acid with chalcones in presence of a base to afford an unexpected (5-Benzoyl-2-hydroxy-2,4-6-triphenyl-cyclohexyl) – phenyl-methanone product. The reaction proceeds via sequential double Michael addition-aldol reaction mediated three consecutive C-C bonds are formed in one pot. The procedure has a short reaction time, easy workup, and moderate yield of products. The structure of all synthesized compounds was determined by using 1HNMR and 13CNMR Spectral analysis.