The reaction OF <i>N</i>‐dichlorophosphoryl‐ <i>P</i>‐trichlorophosphazene with alkyl grignard reagents

Aslan, Fatih; Öztürk, Ali İhsan; Arslan, Mustafa

doi:10.1002/hc.10153

Cited by 11 publications

(3 citation statements)

References 46 publications

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“…The literature contains reports on the synthesis of different linear, cyclic, or poly‐phosphazenes 18–28. The synthesis and different reactions of phosphazenes containing 2,2′‐dioxybiphenyl groups are reported 29, 30.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Biological–Pharmacological Evaluation of New Phosphazenes Bearing Dioxybiphenyl and Schiff Base Groups

Cil¹,

Tanyildizi²,

Özen³

et al. 2012

Archiv der Pharmazie

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A new spirocyclophosphazene, 2,2-bis(2-formylphenoxy)-4,4,6,6-bis[spiro(2',2″-dioxy-1'-1″-biphenylyl)]cyclotriphosphazene (3), was obtained from the reaction of 2,2-dichloro-4,4,6,6-bis[spiro(2',2″-dioxy-1'-1″-biphenylyl)]cyclotriphosphazene (2) with 2-hydroxybenzaldehyde. New phosphazene derivatives bearing Schiff base and dioxybiphenyl groups have been synthesized by the reactions of 3 with different amines. The structures of the compounds were defined by elemental analysis, IR, (1) H, (13) C, and (31) P NMR spectroscopy. All the synthesized compounds were screened for their antibacterial activity against both types of Gram-negative and Gram-positive bacteria. The most potent antibacterial compound of this series was compound 12 which has the low MIC value of 3.75-0.9375 µg/mL. Both minimal inhibitory concentrations (MIC) and inhibition zones were determined in order to monitor the efficacy of the synthesized compounds. New compounds were also screened for anticonvulsant, CNS depressant, and sedative-hypnotic activity. After i.p. injection to mice at doses of 30, 100, and 300 mg/kg body weight phosphazenes were examined in the maximal electroshock-induced seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. Compounds 4, 5, and 11 were found to be active in both MES screen and scPTZ screen at 0.5 h. All except 12 showed more than 44% decrease in locomotor activity after 1 h of compound administration via actophotometer screen. CNS-depressant activity screened with the help of the forced swim method resulted in some potent compounds. Except for 7 and 12 other tested compounds were found to exhibit potent CNS depressants activity as indicated by increased immobility time.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Biological–Pharmacological Evaluation of New Phosphazenes Bearing Dioxybiphenyl and Schiff Base Groups

Cil¹,

Tanyildizi²,

Özen³

et al. 2012

Archiv der Pharmazie

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“…The literature contains reports on the synthesis of different linear or cyclic polyphosphazenes. [6][7][8][9] Furthermore, the properties of phosphazenes can be manipulated by the organic groups connected to the phosphazene ring. Various phosphazene derivatives have been successfully developed for a variety of applications in fields such as biomedical research and medicine, used as ion conductive membranes for rechargeable polymer lithium batteries, fuel cell membranes, microlithography, elastomeric materials, and biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Multistep Synthesis of Phosphazene Derivative of Chenodeoxycholicacid (CDCA)

Türkyılmaz

Genç

2014

Phosphorus, Sulfur, and Silicon and the Related Elements

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“…Syntheses of different linear, cyclic, or polyphosphazenes have been reported [17][18][19][20][21][22][23][24][25][26][27][28][29]. There are also a large number of literature reports on reactions of the functional groups on phosphazene substituents [10,30].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of oxime‐bearing hexakis(2‐formylphenoxy)‐phosphazene and its derivatives

Pamukçi

Cil

Begeç

et al. 2007

Heteroatom Chemistry

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The reaction OF N‐dichlorophosphoryl‐ P‐trichlorophosphazene with alkyl grignard reagents

Abstract: The reactions of N-dichlorophosphoryl-P-trichlorophosphazene Cl 3 P N P(O)Cl -butyl-, cyclopentyl-, iso-propyl-, and ethylmagnesium bromide.

Cited by 11 publications

References 46 publications

Synthesis, Characterization, and Biological–Pharmacological Evaluation of New Phosphazenes Bearing Dioxybiphenyl and Schiff Base Groups

Synthesis, Characterization, and Biological–Pharmacological Evaluation of New Phosphazenes Bearing Dioxybiphenyl and Schiff Base Groups

Multistep Synthesis of Phosphazene Derivative of Chenodeoxycholicacid (CDCA)

Synthesis and characterization of oxime‐bearing hexakis(2‐formylphenoxy)‐phosphazene and its derivatives

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