The Reamer–Irrigator–Aspirator as a Device for Harvesting Bone Graft Compared With Iliac Crest Bone Graft

Dawson, John; Kiner, Dirk; Gardner, Warren E.; Swafford, Rachel; Nowotarski, Peter J.

doi:10.1097/bot.0000000000000086

Cited by 139 publications

(65 citation statements)

References 3 publications

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“…Union rates between ABG and RIA were comparable with 86 and 82 %, respectively. The mean time for union was 22.5 weeks for ABG and 25.8 weeks for RIA [27] demonstrating equivalent results between the treatment modalities of ABG, RIA, and VABG. RIA had furthermore the advantage of significantly less complaints at the donor site over ABG [27], so that RIA can be favored over ABG from the iliac crest due to the aforementioned advantages including cost aspects [27].…”

Section: Ethical Standard Statementmentioning

confidence: 66%

“…A promising alternative to ABG is the RIA-harvested bone grafting, which has been used with an increasing frequency in the past decade. Systematic comparisons between ABG and RIA have been made by Dawson et al [27]. They compared union and complication rates between ABG and RIA as well as donor site complaints and the possible grafting volume in a total number of 133 patients.…”

Section: Resultsmentioning

confidence: 99%

“…Remaining disadvantages of ABG are well known and include harvesting morbidity and limited availability [3,6,27]. Therefore, the use of a VABG seems to be an interesting alternative.…”

Section: Discussionmentioning

confidence: 99%

“…ABG and RIA are the safest and most effective procedures, due to that fact that it contains patient's own bone growing cells (osteogenesis) and proteins (osteoinduction) while providing a frame for the new bone to grow into (osteoconduction). However, ABG and RIA are limited in quantity: approximately 20 cm 3 are available from the anterior iliac crest, 36 cm 3 from the posterior iliac crest, and 37 cm 3 for RIA [27]. Its harvesting is associated with additional comorbidities and donor site complaints with significantly less complaints after RIA [3,20,27].…”

Section: Ethical Standard Statementmentioning

confidence: 97%

“…However, ABG and RIA are limited in quantity: approximately 20 cm 3 are available from the anterior iliac crest, 36 cm 3 from the posterior iliac crest, and 37 cm 3 for RIA [27]. Its harvesting is associated with additional comorbidities and donor site complaints with significantly less complaints after RIA [3,20,27]. In view of these facts, allogenic bone from tissue banks has the advantage of unlimited availability without donor site compilations.…”

Section: Ethical Standard Statementmentioning

confidence: 97%

See 4 more Smart Citations

First mid-term results after cancellous allograft vitalized with autologous bone marrow for infected femoral non-union

Schröter

Ateschrang

Flesch

et al. 2015

Wien Klin Wochenschr

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show abstract

Section: Ethical Standard Statementmentioning

confidence: 66%

Section: Resultsmentioning

confidence: 99%

“…Remaining disadvantages of ABG are well known and include harvesting morbidity and limited availability [3,6,27]. Therefore, the use of a VABG seems to be an interesting alternative.…”

Section: Discussionmentioning

confidence: 99%

Section: Ethical Standard Statementmentioning

confidence: 97%

Section: Ethical Standard Statementmentioning

confidence: 97%

See 3 more Smart Citations

First mid-term results after cancellous allograft vitalized with autologous bone marrow for infected femoral non-union

Schröter

Ateschrang

Flesch

et al. 2015

Wien Klin Wochenschr

View full text Add to dashboard Cite

show abstract

Calcium phosphate incorporated in silk fibroin/methylcellulose based injectable hydrogel: Preparation, characterization, and in vitro biological evaluation for bone defect treatment

2023

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Bone defect is still a challenging problem in orthopedic practice. Injectable bone substitutes that can fill different geometry of bone defect and improve biological environment for bone regeneration are attracting attention. Herein, silk fibroin (SF) is noticeable polymer regarding its biocompatible and biodegradable properties. Thus, the calcium phosphate particles incorporated in silk fibroin/methylcellulose (CAPs‐SF/MC) and only methylcellulose (CAPs‐MC) hydrogels are developed and compared their physicochemical properties. Both CAPs‐hydrogels solutions can be administered with a low injectability force of ~6 N, and they require ~40‐min to change to hydrogel at physiological temperature (37°C). The CAPs are evenly distributed throughout the hydrogel matrix and are capable transformed to bioactive hydroxyapatite at pH 7.4. The CAPs in CAPs‐SF/MC have a smaller size than those in CAPs‐MC. Moreover, CAPs‐SF/MC exhibit gradual degradation, as prediction of the degradation mechanism by the Peppas‐Sahlin model and show a greater ability to sustain CAPs release. CAPs‐SF/MC has good biocompatibility with less cytotoxicity in a dose‐dependent manner on mouse preosteoblast cell line (MC3T3‐E1) when compared to CAPs‐MC. CAPs‐SF/MC hydrogels also have better possibility for promoting cell proliferation and differentiation. In conclusion SF incorporated into composite injectable hydrogel potentially improve biological characteristics and may provide clinical advantages.

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Interaction between living bone particles and rhBMP‐2 in large segmental defect healing in the rat femur

Liu

Wells

Porter

et al. 2016

Journal Orthopaedic Research

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Orthopaedic surgeons sometimes combine recombinant, human BMP -2 with autograft bone when dealing with problematic osseous fractures. Although some case reports indicate success with this off-label strategy, there have been no randomized controlled trials. Moreover, a literature search revealed only one pre-clinical study and this was in a cranial defect model. The present project thus examined the consequences of combining different doses of BMP-2 with particles of living bone in a rat femoral defect model. Human bone particles were recovered with a reamer-irrigator-aspirator. To allow acceptance of the xenograft as surrogate autograft, rats were administered an immunosuppressive cocktail that does not interfere with bone healing. Implantation of 200 μg living bone particles generated a small amount of new bone and defects did not heal. Graded amounts of BMP-2 that alone provoked no healing (1.1 μg), borderline healing (5.5 μg) or full healing (11 μg) were added to this amount of human bone particles. Addition of BMP-2 (1.1 μg) increased osteogenesis, and produced bridging in 2 of 7 defects. The quantitative effects of BMP-2 (5.5 μg) and bone particles were additive at best, but made healing more reliable and advanced the maturation of the regenerate. Bone formation with BMP-2 (11 μg) and bone particles was less than additive, and the major effect was to improve the maturation of the newly formed bone. The data suggest that the combination of autograft and BMP-2 can be helpful clinically under conditions where a healing response is present, but suboptimal.

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The Reamer–Irrigator–Aspirator as a Device for Harvesting Bone Graft Compared With Iliac Crest Bone Graft

Abstract: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.

Cited by 139 publications

References 3 publications

First mid-term results after cancellous allograft vitalized with autologous bone marrow for infected femoral non-union

First mid-term results after cancellous allograft vitalized with autologous bone marrow for infected femoral non-union

Calcium phosphate incorporated in silk fibroin/methylcellulose based injectable hydrogel: Preparation, characterization, and in vitro biological evaluation for bone defect treatment

Interaction between living bone particles and rhBMP‐2 in large segmental defect healing in the rat femur

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