The recent advancement in the PLGA-based thermo-sensitive hydrogel for smart drug delivery

Rahmani, Farzad; Atabaki, Rabi; Behrouzi, S; Mohamadpour, Farnoosh; Kamali, Hossein

doi:10.1016/j.ijpharm.2022.122484

Cited by 26 publications

(13 citation statements)

References 130 publications

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“…The temperature indication of thermo-sensitive hydrogels can be achieved by hydrophilic and hydrophobic groups. For instance, the solubility of the cross-linked network can be adjusted by altering the balance of hydrophilic PEG and hydrophobic PLGA in the PEG-PLGA diblock copolymer-based hydrogel, which ultimately leads to sol-gel phase transition and controlled drug release [19,20].…”

Section: The Classification Of Smart Hydrogelsmentioning

confidence: 99%

From synthesis to modification - a series of optimization strategies for hydrogels as drug delivery carriers

2023

J. Phys.: Conf. Ser.

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In recent years, hydrogels have been gradually used in the fields of biochemistry and medicine due to their unique structure and properties. Particularly, it plays an important role in the application of tissue stents, coating material and drug delivery systems. However, a major problem with these kinds of application is that they can not satisfy some complex requirements due to their limitations such as poor mechanical properties and lack of specific responsiveness. This study aims to provide a set of feasible modification methods to obtain a hydrogel with better performance in all aspects. The blended hydrogel material and semi-interpenetrating network structure are adopted to enhance the mechanical properties of the product and achieve controllability initially. Moreover, the combination of multi-response hydrogels and 3D printing technology is conducive to manufacturing multilayer smartness hydrogels with high functionality and high controllability in a short period at a low cost. The techniques mentioned in this paper can be used in combination to improve the performance of target products and a set of strategies for realizing smart hydrogel is formed. This paper introduces the current status of advanced hydrogel and the development tendency of this material in the future, which provides a theoretical background for the research direction of hydrogel in drug delivery systems for other scholars.

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Section: The Classification Of Smart Hydrogelsmentioning

confidence: 99%

From synthesis to modification - a series of optimization strategies for hydrogels as drug delivery carriers

2023

J. Phys.: Conf. Ser.

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“…The liquid form facilitates injectability into the middle ear and subsequent expulsion via the eustachian tube, while the semisolid form enables prolonged retention in the middle ear, providing sustained drug release. 35,36 Poly(DL-lactic acidco-glycolic acid) (PLGA)−polyethylene glycol (PEG)−PLGA (PLGA-PEG-PLGA), a extensively investigated thermally reversible hydrogel, 37,38 offers several advantages such as biodegradability, water solubility, slow-release properties, rapid gel-forming time, and minimal toxicity. 39,40 Meanwhile, the biodegradable polymer PLGA has been reported as an ideal carrier for preparing microspheres to achieve controllable drug delivery.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the use of biodegradable hydrogels as a continuous drug delivery system to the inner ear has emerged as a promising alternative to multiple injections, offering a longer residence time, reduced risk of infection associated with repeated injections, and prolonged drug effects. ,− To avoid secondary conductive hearing loss resulting from the application of hydrogels in the middle ear, , an ideal middle ear hydrogel should be thermosensitive, allowing it to transition between liquid and semisolid states. The liquid form facilitates injectability into the middle ear and subsequent expulsion via the eustachian tube, while the semisolid form enables prolonged retention in the middle ear, providing sustained drug release. , Poly( dl -lactic acid- co -glycolic acid) (PLGA)–polyethylene glycol (PEG)–PLGA (PLGA-PEG-PLGA), a extensively investigated thermally reversible hydrogel, , offers several advantages such as biodegradability, water solubility, slow-release properties, rapid gel-forming time, and minimal toxicity. , Meanwhile, the biodegradable polymer PLGA has been reported as an ideal carrier for preparing microspheres to achieve controllable drug delivery. The use of PLGA microspheres is crucial for maintaining the activities of proteins or peptides, allowing a single intratympanic injection of the P-G hydrogel to exhibit sustained release. , …”

Section: Introductionmentioning

confidence: 99%

Complete Restoration of Hearing Loss and Cochlear Synaptopathy via Minimally Invasive, Single-Dose, and Controllable Middle Ear Delivery of Brain-Derived Neurotrophic Factor–Poly(dl-lactic acid-co-glycolic acid)-Loaded Hydrogel

Yu,

Liu,

Guo

et al. 2024

ACS Nano

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Noise-induced hearing loss (NIHL) often accompanies cochlear synaptopathy, which can be potentially reversed to restore hearing. However, there has been little success in achieving complete recovery of sensorineural deafness using nearly noninvasive middle ear drug delivery before. Here, we present a study demonstrating the efficacy of a middle ear delivery system employing brain-derived neurotrophic factor (BDNF)−poly-(DL-lactic acid-co-glycolic acid) (PLGA)-loaded hydrogel in reversing synaptopathy and restoring hearing function in a mouse model with NIHL. The mouse model achieved using the single noise exposure (NE, 115 dBL, 4 h) exhibited an average 20 dBL elevation of hearing thresholds with intact cochlear hair cells but a loss of ribbon synapses as the primary cause of hearing impairment. We developed a BDNF-PLGA-loaded thermosensitive hydrogel, which was administered via a single controllable injection into the tympanic cavity of noise-exposed mice, allowing its presence in the middle ear for a duration of 2 weeks. This intervention resulted in complete restoration of NIHL at frequencies of click, 4, 8, 16, and 32 kHz. Moreover, the cochlear ribbon synapses exhibited significant recovery, whereas other cochlear components (hair cells and auditory nerves) remained unchanged. Additionally, the cochlea of NE treated mice revealed activation of tropomyosin receptor kinase B (TRKB) signaling upon exposure to BDNF. These findings demonstrate a controllable and minimally invasive therapeutic approach that utilizes a BDNF-PLGA-loaded hydrogel to restore NIHL by specifically repairing cochlear synaptopathy. This tailored middle ear delivery system holds great promise for achieving ideal clinical outcomes in the treatment of NIHL and cochlear synaptopathy.

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“…are some examples of proteins. Poly (lactic- co -glycolic acid) (PLGA), 11 polyvinyl pyrrolidone (PVP), 12 etc . are examples of synthetic polymers.…”

Section: Introductionmentioning

confidence: 99%

The engineering and application of extracellular matrix hydrogels: a review

Zhang

2023

Biomater. Sci.

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The recent advancement in the PLGA-based thermo-sensitive hydrogel for smart drug delivery

Cited by 26 publications

References 130 publications

From synthesis to modification - a series of optimization strategies for hydrogels as drug delivery carriers

From synthesis to modification - a series of optimization strategies for hydrogels as drug delivery carriers

Complete Restoration of Hearing Loss and Cochlear Synaptopathy via Minimally Invasive, Single-Dose, and Controllable Middle Ear Delivery of Brain-Derived Neurotrophic Factor–Poly(dl-lactic acid-co-glycolic acid)-Loaded Hydrogel

The engineering and application of extracellular matrix hydrogels: a review

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