The recent development of topical nanoparticles for annihilating skin cancer

Saindane, Dnyanesh; Bhattacharya, Subhamoy; Shah, Rahul K.; Prajapati, Bhupendra G.

doi:10.1080/26895293.2022.2103592

Cited by 10 publications

(4 citation statements)

References 201 publications

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“…Metallic nanoparticles, which are composed of gold, silver, and metallic oxides, are commercially available and are being researched for use in the dermal delivery of active pharmaceutical ingredients. The particles in the metallic nanoparticles are aggregated on the surface and do not have any adverse effects on the epidermis [128]. These nanoparticlebased formulations have not yet received FDA approval in topical/dermal skin cancer therapy, even though nanoparticle-based therapy is receiving significant awareness and interest for the therapy of skin cancer and different disorders [129].…”

Section: Nanoparticles For Skin Cancermentioning

confidence: 99%

Recent advancements in skin cancer treatment: a critical review

Goyal,

Husain,

Wilson

et al. 2023

Exploration of Medicine

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The prevalence of skin cancer has increased hastily in the recent decade for both kinds of melanoma and non-melanoma skin cancer. Skin cancers mostly encompass keratinocyte cancers: cutaneous squamous cell carcinoma, basal cell carcinoma, and melanoma. This review discusses the recent advancements in the treatment of skin cancer. In addition to chemotherapy, immunotherapy, targeted therapy, and photodynamic therapy (PDT), there are several other therapies for skin cancer. Additionally, PDT use in combination with chemotherapy, radiation, immunotherapy, and surgery is being actively investigated. This review will specifically address the pathophysiology of skin cancer, diagnostic approaches, and current therapies used in the topical treatment of skin cancers and introduce emerging treatment using nanotechnology that may be beneficial for these indications.

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Section: Nanoparticles For Skin Cancermentioning

confidence: 99%

Recent advancements in skin cancer treatment: a critical review

Goyal,

Husain,

Wilson

et al. 2023

Exploration of Medicine

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show abstract

“…Besides, nanoparticle-based drug delivery can enhance drug retention with tunable release kinetics at the disease site inside the skin . Skin entry of nanoparticles through the transappendageal route, which includes the hair follicles, sweat glands, and the sebaceous and pilosebaceous glands, has been reported. , This enables nanoparticles to penetrate the superficial layers of the stratum corneum, i.e., the outermost protective layer of the skin.…”

Section: Introductionmentioning

confidence: 99%

“…9 Skin entry of nanoparticles through the transappendageal route, which includes the hair follicles, 10 sweat glands, and the sebaceous and pilosebaceous glands, has been reported. 11,12 This enables nanoparticles to penetrate the superficial layers of the stratum corneum, i.e., the outermost protective layer of the skin. However, the transappendageal route covers only 0.1% of the total skin surface.…”

Section: ■ Introductionmentioning

confidence: 99%

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

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Skin, the largest organ in humans, is an efficient route for the delivery of drugs as it circumvents several disadvantages of the oral and parenteral routes. These advantages of skin have fascinated researchers in recent decades. Drug delivery via a topical route includes moving the drug from a topical product to a locally targeted region with dermal circulation throughout the body and deeper tissues. Still, due to the skin's barrier function, delivery through the skin can be difficult. Drug delivery to the skin using conventional formulations with micronized active components, for instance, lotions, gels, ointments, and creams, results in poor penetration. The use of nanoparticulate carriers is one of the promising strategies, as it provides efficient delivery of drugs through the skin and overcomes the disadvantage of traditional formulations. Nanoformulations with smaller particle sizes contribute to improved permeability of therapeutic agents, targeting, stability, and retention, making nanoformulations ideal for drug delivery through a topical route. Achieving sustained release and preserving a localized effect utilizing nanocarriers can result in the effective treatment of numerous infections or skin disorders. This article aims to evaluate and discuss the most recent developments of nanocarriers as therapeutic agent vehicles for skin conditions with patent technology and a market overview that will give future directions for research. As topical drug delivery systems have shown great preclinical results for skin problems, for future research directions, we anticipate including in-depth studies of nanocarrier behavior in various customized treatments to take into account the phenotypic variability of the disease.

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“…Additionally, delivery using nanoparticles at the inside the skin can improve drug and ingredient retention with controllable release kinetics [ 17 ]. It has been documented that nanoparticles can enter the skin by the trans appendageal route, which passes through the sebaceous and pilosebaceous glands, sweat glands, and hair follicles [ 18 , 19 ]. This makes it possible for nanoparticles to enter the stratum corneum, the skin’s outermost layer of defense.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Nanobubbles on Transdermal Applications

Mitropoulos,

Pappa,

Kosheleva

et al. 2023

Nanomaterials

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In the present work, a new method for dermal delivery using nanobubbles (NBs) is investigated. Oxygen NBs are generated in deionized water and used to produce cosmetic formulations with hyaluronic acid as an active ingredient. Nanobubbles result in the improvement of the effect and penetration of the active ingredient through Strat-M, a synthetic membrane that resembles human skin. Experiments conducted with the Franz Cell device confirm the greater penetration of the active ingredient into Strat-M due to NBs, compared to cosmetic formulations that do not contain NBs. The effect of NBs was further examined by measuring UV-Vis and FTIR spectra. A possible mechanism was outlined, too. It was also found that NBs do not change the pH or the FTIR spectrum of the cosmetic serum indicating non-toxicity.

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The recent development of topical nanoparticles for annihilating skin cancer

Cited by 10 publications

References 201 publications

Recent advancements in skin cancer treatment: a critical review

Recent advancements in skin cancer treatment: a critical review

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

The Effect of Nanobubbles on Transdermal Applications

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