2011
DOI: 10.2119/molmed.2011.00414
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The Receptor That Tames the Innate Immune Response

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Cited by 117 publications
(107 citation statements)
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“…Observational data from preterm infants who suffered from IVH and who were treated with rEPO to prevent red blood cell transfusions showed improved long-term neurodevelopmental outcomes when assessed at 3 years of age or more [23]. As they received rEPO within days or weeks after the insult, the proposed mode of action of rEPO is thought to be the facilitation of repair, the sustainment of neuronal growth and differentiation after brain injury, rather than protection against damage [24]. …”
Section: Potential Benefits and Risks Of Erythropoietin In Preterm Inmentioning
confidence: 99%
“…Observational data from preterm infants who suffered from IVH and who were treated with rEPO to prevent red blood cell transfusions showed improved long-term neurodevelopmental outcomes when assessed at 3 years of age or more [23]. As they received rEPO within days or weeks after the insult, the proposed mode of action of rEPO is thought to be the facilitation of repair, the sustainment of neuronal growth and differentiation after brain injury, rather than protection against damage [24]. …”
Section: Potential Benefits and Risks Of Erythropoietin In Preterm Inmentioning
confidence: 99%
“…More recently, EpoR expression has been reported for T and B lymphocytes, monocytes as well as macrophages and dendritic cells (Arcasoy, 2010;Lisowska et al, 2010), but its function seems to be cell type specific. While in most cells an antiinflammatory function was described (Brines and Cerami, 2012), dendritic cells seem to display an activated phenotype in the presence of Epo (Prutchi Sagiv et al, 2008;Rocchetta et al, 2011). Mast cells, apart from their well-known role in allergy, also are part of the host's innate immune system.…”
Section: Discussionmentioning
confidence: 99%
“…In the past years it was shown that the EpoR is not expressed exclusively on erythroid cells but also on myeloid immune cells (Brines and Cerami, 2012). We therefore investigated whether murine bone marrow-derived mast cells (BMMCs) express the EpoR.…”
Section: The Erythropoietin Receptor Is Expressed By Murine Mast Cellsmentioning
confidence: 99%
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