The recognition and treatment of vertebral fractures in males with chronic obstructive pulmonary disease

Carter, John D.; Patel, Shuchita Dhwiren; Sultan, Farah; Thompson, Zachary; Margaux, Hemstreet; Sterrett, Ashley; Carney, Gregory; Murphy, Nancy G.; Huang, Yangxin; Valeriano, Joanne; Vasey, Frank B.

doi:10.1016/j.rmed.2008.03.003

Cited by 36 publications

(22 citation statements)

References 31 publications

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“…The relationship between osteoporosis and functional limitation is uncertain but likely to be important as fractures remain a daunting problem in the elderly. Vertebral compression fractures are relatively common among COPD patients and the resultant increased kyphosis may further reduce pulmonary function [124].…”

Section: Osteoporosismentioning

confidence: 99%

Systemic manifestations and comorbidities of COPD

Barnes¹,

Celli²

2009

Eur Respir J

1,476

1,113

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Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a complex disease involving more than airflow obstruction. Airflow obstruction has profound effects on cardiac function and gas exchange with systemic consequences. In addition, as COPD results from inflammation and/or alterations in repair mechanisms, the ''spill-over'' of inflammatory mediators into the circulation may result in important systemic manifestations of the disease, such as skeletal muscle wasting and cachexia. Systemic inflammation may also initiate or worsen comorbid diseases, such as ischaemic heart disease, heart failure, osteoporosis, normocytic anaemia, lung cancer, depression and diabetes. Comorbid diseases potentiate the morbidity of COPD, leading to increased hospitalisations, mortality and healthcare costs. Comorbidities complicate the management of COPD and need to be evaluated carefully. Current therapies for comorbid diseases, such as statins and peroxisome proliferator-activated receptor-agonists, may provide unexpected benefits for COPD patients. Treatment of COPD inflammation may concomitantly treat systemic inflammation and associated comorbidities. However, new broad-spectrum anti-inflammatory treatments, such as phosphodiesterase 4 inhibitors, have significant side-effects so it may be necessary to develop inhaled drugs in the future. Another approach is the reversal of corticosteroid resistance, for example with effective antioxidants. More research is needed on COPD comorbidities and their treatment.

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Section: Osteoporosismentioning

confidence: 99%

Systemic manifestations and comorbidities of COPD

Barnes¹,

Celli²

2009

Eur Respir J

1,476

1,113

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“…However, as suggested in other reports [16,41], a more careful evaluation of lateral chest X-rays, driven by educational initiatives addressed to improve the probably low sensitivity of both radiologists and internists in assessing the presence of VFs, could be quite an easily achievable goal. Finally, a large body of evidence exists that bone loss and frailty fractures are closely associated with COPD [6,35,42,43], and that the incidence of VFs may aggravate the clinical condition in these patients [37]. Consequently, it appears mandatory that bone loss and its sequelae should be given top prominence in the therapeutic strategy for patients with this disorder in Internal Medicine, as well as in Respiratory Disease Units.…”

Section: Discussionmentioning

confidence: 99%

High prevalence of fragility vertebral fractures in patients hospitalised in Internal Medicine Units. Results of the POINT (Prevalence of Osteoporosis in INTernal medicine) study

Vitali¹,

Gussoni

Bianchi

et al. 2015

Bone

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“…Aunque se ha dilucidado ampliamente el efecto de las deformidades torácicas sobre la función respiratoria en ciertos grupos poblacionales, pocos estudios han evaluado el impacto sobre individuos con EPOC. En el estudio de Carter et al, se observó el efecto de las fracturas de compresión vertebral sobre los cambios en la morfología y la movilidad de la caja torácica y su impacto deletéreo sobre la función pulmonar (9).…”

Section: Dmo (Mg/ml)= 0767 X Unidades Hounsfieldunclassified

Osteoporosis, fracturas vertebrales e hipercifosis en la enfermedad pulmonar obstructiva crónica

Rivero

Franco

Duque

2016

rev. colomb. neumol.

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La enfermedad pulmonar obstructiva crónica (EPOC) es una condición frecuente con repercusiones sistémicas, dentro de las que se encuentra la osteoporosis. Las fracturas vertebrales derivan del compromiso de la masa ósea y promueven la aparición de deformidades vertebrales. La hipercifosis es una de las alteraciones más frecuentes del segmento dorsal de la columna y le impone a quien la padece un impacto negativo sobre su capacidad funcional general. La sobreposición EPOC/hipercifosis podría modificar el curso clínico del enfermo respiratorio debido a que puede causar mayor compromiso de la mecánica respiratoria y la función pulmonar. La información acerca de esta sobreposición sigue siendo poca. Es necesario realizar estudios para determinar la prevalencia de las deformidades de la columna vertebral en pacientes con EPOC y su impacto real en la función pulmonar y en el curso clínico de la enfermedad.

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The recognition and treatment of vertebral fractures in males with chronic obstructive pulmonary disease

Cited by 36 publications

References 31 publications

Systemic manifestations and comorbidities of COPD

Systemic manifestations and comorbidities of COPD

High prevalence of fragility vertebral fractures in patients hospitalised in Internal Medicine Units. Results of the POINT (Prevalence of Osteoporosis in INTernal medicine) study

Osteoporosis, fracturas vertebrales e hipercifosis en la enfermedad pulmonar obstructiva crónica

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