The recovery time required for rat joint contractures treated with joint fixation with unweighting of the hind limbs

Sato, Yuta; Ono, Takeya; Ishikura, Hiroto; Aihara, Kazuki; Tasaka, Atsushi; Umei, Namiko; Tsumiyama, Wakako; Oki, Sadaaki

doi:10.1589/jpts.31.336

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…According to research, full recovery of joint movements after 30 days of immobilization does not occur for eight weeks [6] according to Sato Y. et al [7], only on the 32nd week, when the animals are kept freely, it is possible to talk about the restoration of movements.…”

Section: методи та методики / Methods and Methodologiesmentioning

confidence: 99%

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FORMATION OF IMMOBILIZATION CONTRACTURE OF THE KNEE JOINT IN LABORATORY ANIMALS AND RESTORATION OF ITS FUNCTIONALITY UNDER THE INFLUENCE OF LOW-FREQUENCY VIBRATION (experimental study)

Khasawneh

Karpinska

2023

VPBM

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Connection of the publication with planned research works.The research was carried out with the scientific topic "To study the mechanisms of formation of immobilization contractures and to investigate the effect of low-frequency vibration on the restoration of joint function", state registration number 0121U111555. Introduction.The term "joint contractures" describes the loss of the passive range of motion of diarthrosis joints, the most common and mobile type of joint. Measuring the passive or active range of motion of a contracture joint is critical to assessing the importance of joint contractures [1]. Joint contractures caused by immobility have both myogenic and arthrogenic components. In a rat model, less than two weeks of immobilisation periods produced contractures associated with muscle restriction, and the contractures were reversible after remobilisation. In the case of immobilisation for four or more weeks, the joint structures contributed more to limiting the range of motion, and the resulting contractures were irreversible [2,3].The aim of the study.To determine the impact of immobilization on the formation of contracture of the knee joint in laboratory animals (rats) and to evaluate the possibility of restoring mobility in the case of using low-frequency vibration during and after immobilization.Object and research methods.Joint contractures are loss of passive range of motion of the diarthrosis joint. Immobilization contractures are one of the common types of joint contractures. The study aimed to determine the effect of immobilization on the formation of knee joint contracture in laboratory animals (rats) and assess the possibility of restoring mobility using low-frequency vibration during and after immobilization. Three groups of laboratory rats, ten animals each, were studied: I -4 weeks of immobilization, 4 weeks of observation without rehabilitation measures; II -4 weeks of immobilization, 4 weeks of low-frequency therapy; III -4 weeks of immobilization, and 4 weeks in a row rats received a course of vibration therapy. The knee joint range of motion was measured weekly. Vibration development was carried out in the mode of 20 Hz with an amplitude of 1.5 mm. The rapid growth of contracture occurs from the 2nd week of immobilization. In the animals of the I and II groups, the process happened in the same way. In the III group, contractures were formed by the 4th week, but significantly less than in the previous groups. After the removal of immobilization, a slow increase in movements was observed in the first group, which did not reach average values by the 4th week after the removal of immobilization. Group II rats had a rapid reduction in contracture, and recovery occurred by week 4. In the III group, recovery was complete in 2 weeks. Low-frequency vibration reduces the impact of immobilization and significantly accelerates the recovery of the joint after its completion.

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Section: методи та методики / Methods and Methodologiesmentioning

confidence: 99%

“…за даними Sato Y. et al[7] тільки на 32 тиждень при вільному утриманні тварин можна говорити про відновлення рухів.…”

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FORMATION OF IMMOBILIZATION CONTRACTURE OF THE KNEE JOINT IN LABORATORY ANIMALS AND RESTORATION OF ITS FUNCTIONALITY UNDER THE INFLUENCE OF LOW-FREQUENCY VIBRATION (experimental study)

Khasawneh

Karpinska

2023

VPBM

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Effect of Number of Days Free Breeding on Joint Contracture in Rats

et al. 2022

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The purpose of this study was to clarify the effect of number of days free breeding on ankle joint contracture. [Participants and Methods] The right ankle joint of rats was immobilized at maximum plantar flexion with hindlimb suspension, and the immobilization was removed on the 8th day. After that, rats were divided into three groups: a 7-day free breeding group, a 6-day free breeding group, and a 0-day free breeding group. [Results] There were no significant differences in the dorsiflexion range of motion of the ankle joint among the three groups on the 8th day after the removal of immobilization. On day 14, the last day of the experiment, the 7-day free breeding group showed significantly better dorsiflexion range of motion of the ankle joint than the other two groups, but there was no significant difference between the 6-day and 0-day free breeding groups. [Conclusion] Free breeding ankle joint range of motion was improved more than that of the unloaded hindlimb suspension condition. On the other hand, the free breeding condition may have overloaded the joint contractures.

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ラット膝窩部における関節包の生体力学的特性に関する研究

SUGAHARA,

ONO,

SATO

et al. 2023

Rigakuryoho kagaku

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The purpose of this study was to clarify the biomechanical properties of the capsule in a normal rat knee joint. [Participants and Methods] Femur-capsule-tibia composite specimens prepared from the hindlimbs of five 8-week-old male Wistar rats were subjected to tensile testing. [Results] The waveforms of the length-tension curves showed steep and repeated declines in some individual rats (three out of five samples) while in others (two out of five samples) they were not repeated. [Conclusion] It was found that some capsules in the rat knee fossa had a mixture of cruciate ligament-like fibers while others did not.

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The recovery time required for rat joint contractures treated with joint fixation with unweighting of the hind limbs

Cited by 6 publications

References 11 publications

FORMATION OF IMMOBILIZATION CONTRACTURE OF THE KNEE JOINT IN LABORATORY ANIMALS AND RESTORATION OF ITS FUNCTIONALITY UNDER THE INFLUENCE OF LOW-FREQUENCY VIBRATION (experimental study)

FORMATION OF IMMOBILIZATION CONTRACTURE OF THE KNEE JOINT IN LABORATORY ANIMALS AND RESTORATION OF ITS FUNCTIONALITY UNDER THE INFLUENCE OF LOW-FREQUENCY VIBRATION (experimental study)

Effect of Number of Days Free Breeding on Joint Contracture in Rats

ラット膝窩部における関節包の生体力学的特性に関する研究

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