The recreational tryptamine 5-MeO-DALT (N,N-diallyl-5-methoxytryptamine): A brief review

Abstract

5-MeO-DALT (N,N-diallyl-5-methoxytryptamine) is a psychoactive substance, sold primarily over the Internet as a 'research chemical' or 'plant food'. Although details for the synthesis of this tryptamine have been available since 2004, its use as a hallucinogenic drug has been reported only occasionally in on-line user fora. It is controlled in only a few countries world-wide. There is little scientifically-based literature on the pharmacological, physiological, psychopharmacological, toxicological and epidemiological characteristics of 5-MeO-DALT. Here we review what is known about these aspects. We also report what we believe to be the first death involving the use of this substance. The case involved a man in his mid-20s who died in mid-2010. The coroner concluded that the deceased "died from injuries sustained after being hit by a lorry whilst under the influence of 5-MeODALT". It is critical that any other cases, including non-fatal instances, are documented so that a scientific evidence-base can be established for this drug.

Biotransformation and detectability of the new psychoactive substances N,N-diallyltryptamine (DALT) derivatives 5-fluoro-DALT, 7-methyl-DALT, and 5,6-methylenedioxy-DALT in urine using GC-MS, LC-MSn, and LC-HR-MS/MS

“…[5,6]. N,N-Diallyltryptamine (DALT) derivatives represent an important group with 5-methoxy-DALT (5-MeO-DALT) being the most often reported example [7][8][9]. As such drugs may become controlled the creation of new substances with similar chemical structures and effects is aimed at circumventing legislative restrictions [5], which leads to significant challenges for drug testing laboratories in the attempt to be kept up-to-date with analytical methods and reference data [10,11].…”

Novel psychoactive substances: types, mechanisms of action, and effects

“…56 Unlike established recreational psychedelics, some NPS hallucinogens also have stimulant properties, and these have increased risk of acute toxicity, including agitation, hallucinations, tachycardia, hypertension, hyperthermia, rhabdomyolysis, serotonin syndrome, and seizures. [57][58][59][60][61] There is currently little evidence of longer term health risks or addiction. 56…”

Biomedical Significance of Tryptamine: A Review

“…The indole ring is the important nucleus of many complex natural products having importance in drug discovery and a variety of naturally occurring, synthetic and semi-synthetic drugs are based on tryptamine skeleton. Tryptamine is found in fungi, plants and animals [2]. Tryptamine structural distinction is in approximation to the neurotransmitter serotonin and as hallucinogens and well-known drugs in these classes are DMT etc.…”