The recurrence risk of the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP) in subsequent gestations

Sullivan, Christopher A.; Magann, Everett F.; Perry, Kenneth G.; Roberts, William S.; Blake, Pamela G.; Martin, James N.

doi:10.1016/s0002-9378(94)70063-x

Cited by 147 publications

(61 citation statements)

References 11 publications

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“…With prior preeclampsia (of any type), the risk of recurrent preeclampsia in a subsequent pregnancy varies widely (median 15%) , as does ''severe'' recurrent preeclampsia (median 15%) [170,175,176,181,182,184,188,[192][193][194][195]. Recurrence is more likely when prior preeclampsia was: of early onset [184,188,194], ''severe'' [169,187], or complicated by eclampsia [192,193,196] or HELLP syndrome [176,177,182,188]. Higher BMI in prior preeclampsia increases the recurrence risk [185].…”

Section: Commentsmentioning

confidence: 99%

RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

Magee

Pels

Helewa

et al. 2008

Journal of Obstetrics and Gynaecology Canada

421

218

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Section: Commentsmentioning

confidence: 99%

RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

Magee

Pels

Helewa

et al. 2008

Journal of Obstetrics and Gynaecology Canada

421

218

View full text Add to dashboard Cite

“…Some of the predisposing factors include diabetes mellitus (14), increased insulin resistance (14), hypertension (8), black race (15), and high body mass index (BMI) (15). Pregnancies with large placentas (as in twin pregnancies, diabetic pregnancies and hydatidiform moles), primigravidas, and a previous pregnancy with preeclampsia (16), increase the risk of developing preeclampsia. A new sexual partner and the use of barrier contraception are both associated with an increased risk of developing preeclampsia, whereas previous antigen exposure is protective (17).…”

Section: Risk Factors For Preeclampsiamentioning

confidence: 99%

The decidual suction method: a new way of collecting decidual tissue for functional and morphological studies

Harsem¹,

Staff²,

et al. 2004

Acta Obstet Gynecol Scand

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Background. Studies of extravillous trophoblasts and placental bed spiral arteries are essential for a better understanding of pathological pregnancies such as preeclampsia, intrauterine growth restriction and diabetes mellitus. A major challenge is to obtain representative and sufficient tissue for morphological and functional investigations. Currently, tissue material is mostly harvested by placental bed biopsy (PBB). We describe a new suction method to obtain a larger volume of decidual tissue from the placental bed. Methods. Tissue was harvested in 51 cesarean sections by vacuum suction of the placental bed. Sections from formalin‐fixed, paraffin‐embedded tissue were routinely stained with hematoxylin and eosin (H&E), immunostained with a panel of antibodies and morphologically examined for the presence of trophoblasts and spiral arteries. The results were compared with those from archive material from PBBs and placental basal plate sections (BPSs). Short‐term adverse events were registered for the study patients. Long‐term complications were registered from medical charts of 151 women having undergone the decidual suction method (DSM), with a follow‐up of 38–60 months. Results. In 86% (n = 44), one random section from the decidual suction material demonstrated at least one spiral artery. In 37% (n = 19), six or more spiral arteries were present. All sections revealed extravillous trophoblasts. No short‐ or long‐term morbidity was recorded. Conclusions. The decidual suction method represents an important improvement in the work to obtain sufficient decidual tissue for morphological and functional studies of extravillous trophoblast function and spiral artery adaptation. The method is safe, as no short‐ or long‐term complications were registered.

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“…Our main objectives were early detection of risk factors and their treatment, prevention of progression to severe disease and early intervention to prevent maternal death and morbidity. Maternal complications in such cases are disseminated intravascular coagulation (DIC) (6%-20%), placental abruption (16%), acute renal failure (7%) and pulmonary edema [2]. Caesarean section is required to terminate pregnancy for various reason however, platelet count less than 70,000/cu.mm is contraindication for spinal or epidural anesthesia [3].…”

Section: Discussionmentioning

confidence: 99%

HELLP Syndrome: Report of Three Cases with Review of Literature.

Pa¹

2016

JCR

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Abstract:Unexpected and fulminant course of HELLP syndrome as well as absence of classical signs of preeclampsia can confuse physician and lead to rapid maternal death. We present three different cases of HELLP syndrome, two antenatal cases with associated severe preeclampsia and one post Caesarean section without associated preeclampsia. We discuss the challenges in diagnosis, management, and outcome which will eventually may help to optimize treatment outcome in these patients.

show abstract

The recurrence risk of the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP) in subsequent gestations

Cited by 147 publications

References 11 publications

RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

The decidual suction method: a new way of collecting decidual tissue for functional and morphological studies

HELLP Syndrome: Report of Three Cases with Review of Literature.

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