The Red Alga<i>Gracilariopsis chorda</i>and Its Active Constituent Arachidonic Acid Promote Spine Dynamics via Dendritic Filopodia and Potentiate Functional Synaptic Plasticity in Hippocampal Neurons

Mohibbullah, Md.; Choi, Jae‐Suk; Bhuiyan, Mohammad Maqueshudul Haque; Haque, Nazmul; Rahman, Khalilur; Moon, Il Soo; Hong, Yong‐Ki

doi:10.1089/jmf.2017.4026

Cited by 13 publications

(12 citation statements)

References 26 publications

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“…Fucoxanthin has shown to exhibit neurite outgrowth activity (15.7–31% of cells to develop neurite outgrowth) at much lower concentrations (0.1–2 μM), in the absence of NGF support, indicating that this marine carotenoid could a potential neurotrophic molecule [ 136 ]. Gracilariopsis chorda and its active compound arachidonic acid modulated spine dynamics, and potentiated functional synaptic plasticity of hippocampal neurons [ 150 ].…”

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

“…Porphyra yezoensis and its compound taurine facilitated neuronal development and maturation of primary hippocampal neurons [ 152 ]. Gelidium amansii [ 153 , 154 , 155 , 156 ], Sargassum fulvellum [ 157 ], Undaria pinnatifida and Saccharina japonica [ 158 ], Gracilariopsis chorda [ 150 , 159 ], and carrageenophyte Kappaphycus alvarezii [ 160 , 161 , 162 , 163 ] promoted neuronal morphology and functions. Of these, G. amansii that exhibited neuromodulatory potentials in several studies [ 153 , 154 , 155 , 156 ] could be the most promising candidate for further isolation of neurotrophic agents and thus expects special attention of natural product chemists.…”

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

“…Glycoproteins isolated from Capsosiphon fulvescens ameliorated aging-induced spatial memory deficits by attenuating GSK-3β-mediated ER stress in rat dorsal hippocampus [ 221 ] and promoted probiotics-induced cognitive improvement in aged rat model [ 222 ]. Gracilariopsis chorda and its active compound arachidonic acid, given independently through oral route for 10 days, improved scopolamine-induced memory impairment in mice [ 150 ].…”

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

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Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

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Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. As was evident in various preclinical studies, algal compounds conferred neuroprotection against a wide range of neurotoxic stressors, such as oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for brain disorders. While a significant number of algal compounds with promising neuroprotective capacity have been identified over the last decades, a few of them have had access to clinical trials. However, the recent approval of an algal oligosaccharide, sodium oligomannate, for the treatment of Alzheimer’s disease enlightened the future of marine algae-based drug discovery. In this review, we briefly outline the pathophysiology of neurodegenerative diseases and brain injuries for identifying the targets of pharmacological intervention, and then review the literature on the neuroprotective potentials of algal compounds along with the underlying pharmacological mechanism, and present an appraisal on the recent therapeutic advances. We also propose a rational strategy to facilitate algal metabolites-based drug development.

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Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

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Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

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“…Fatty acid is an important nutritional component that provides promising health benefits [39]. The study revealed a higher amount of omega-3 fatty acids, particularly DHA and EPA, found in hot smoked HDPS products, which are known to be effective in mitigating the onset of neurodegenerative complications in central nervous system neurons, cardiovascular disease progression, and arthritis [40][41][42]. PAHs are generally formed from incomplete combustion of organic matter such as wood materials while smoking and considered to be potential health hazards, in which BaP represents an effective genotoxic and carcinogenic to humans [43].…”

Section: Discussionmentioning

confidence: 99%

Improvement of Sensorial, Physicochemical, Microbiological, Nutritional and Fatty Acid Attributes and Shelf Life Extension of Hot Smoked Half-Dried Pacific Saury (Cololabis saira)

Baten

Won

Sohn

et al. 2020

Foods

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Half-dried Pacific saury of Cololabis saira (HDPS) is a fatty fish of high nutritional value with remarkable consumer interest in the Asia Pacific region, however, it undergoes various deteriorative changes associated with browning, bacterial contamination, oxidation, and decreased sensory attributes while marketed in various processed forms. To withstand these complications, research aimed to investigate the hot smoking technology to improve physicochemical, microbiological, and sensory attributes of HDPS with prolonged shelf life in storage conditions. The HDPS fillets were processed with hot smoking (70 °C) using various sawdust materials of Apple, Chestnut, Oak, Cherry, and Walnut, wherein the smoke time was set at different time points of 0, 20, 25, and 30 min. The results indicated that 25 min of smoking time with the selective Oak sawdust showed better sensorial characteristics, physicochemical properties, and microbiological qualities. Moreover, HDPS possessed higher nutritional value and valuable functional fatty acids, particularly docosahexaenoic acid and eicosapentaenoic acid, having a storage ability of up to 30 days at 10 °C. The processed HDPS offered a reduced level of Trimethylamine-N-oxide and Benzo[a]pyrene contents, indicating the acceptable and safe for human consumption. Therefore, HDPS with hot smoking could likely be a promising technique for preserving the premium quality of the product by providing desired characteristics of health and nutrition to end-point consumers.

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“…Fucoxanthin has shown to exhibit neurite outgrowth activity (15.7-31% of cells to develop neurite outgrowth) at much lower concentrations (0.1-2 μM), in the absence of NGF support, indicating that this marine carotenoid could a potential neurotrophic molecule [107]. Gracilariopsis chorda and its active compound arachidonic acid modulated spine dynamics, and potentiated functional synaptic plasticity of hippocampal neurons [140].…”

Section: Neurotrophic Activitymentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Hannan¹,

Dash²,

Haque³

et al. 2020

Preprint

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Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. As was evident in various preclinical studies, algal compounds conferred neuroprotection against a wide range of neurotoxic stressors, such as oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for brain disorders. While a significant number of algal compounds with promising neuroprotective capacity have been identified over the last decades, a few of them have had access to clinical trials. However, the recent approval of an algal oligosaccharide, sodium oligomannate, for the treatment of Alzheimer's disease enlightened the future of marine algae-based drug discovery. In this review, we briefly outline the pathophysiology of neurodegenerative diseases and brain injuries for identifying the targets of pharmacological intervention, and then review the literature on the neuroprotective potentials of algal compounds along with the underlying pharmacological mechanism, and present an appraisal on the recent therapeutic advances. We also propose a rational strategy to facilitate algal metabolites-based drug development.

show abstract

The Red AlgaGracilariopsis chordaand Its Active Constituent Arachidonic Acid Promote Spine Dynamics via Dendritic Filopodia and Potentiate Functional Synaptic Plasticity in Hippocampal Neurons

Cited by 13 publications

References 26 publications

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Improvement of Sensorial, Physicochemical, Microbiological, Nutritional and Fatty Acid Attributes and Shelf Life Extension of Hot Smoked Half-Dried Pacific Saury (Cololabis saira)

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

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