The red lens: a case of florid lens neovascularisation

Roy, Rupak; Saurabh, Kumar; Srivastava, Prashant; Pal, Swakshyar Saumya; Nandi, Krishnendu; Kochgaway, Lav; Biswas, Rupak; Sinha, Sourav

doi:10.1111/cxo.13029

Cited by 8 publications

(7 citation statements)

References 5 publications

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“…Deletion of VEGFA can lead to reduced vascular membrane production, resulting in smaller lenses with mild nuclear turbidity after birth, while overexpression can lead to excessive capillary formation and endothelial cell proliferation and deposition ( Ash and Overbeek, 2000 ; Mitchell et al, 2006 ; Garcia et al, 2009 ). Ocular ischemia or inflammation may lead to the entry of VEGF into the lens capsule, resulting in the formation of new blood vessels ( Roy et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Integrative transcriptomic profiling of ncRNAs and mRNAs in developing mouse lens

Zhang,

Liu,

et al. 2024

Front. Genet.

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In recent years, burgeoning research has underscored the pivotal role of non-coding RNA in orchestrating the growth, development, and pathogenesis of various diseases across organisms. However, despite these advances, our understanding of the specific contributions of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) to lens development remains notably limited. Clarifying the intricate gene regulatory networks is imperative for unraveling the molecular underpinnings of lens-related disorders. In this study, we aimed to address this gap by conducting a comprehensive analysis of the expression profiles of messenger RNAs (mRNAs), lncRNAs, and circRNAs at critical developmental time points of the mouse lens, encompassing both embryonic (E10.5, E12.5, and E16.5) and postnatal stages (P0.5, P10.5, and P60). Leveraging RNA-sequencing technology, we identified key transcripts pivotal to lens development. Our analysis revealed differentially expressed (DE) mRNAs, lncRNAs, and circRNAs across various developmental stages. Particularly noteworthy, there were 1831 co-differentially expressed (CO-DE) mRNAs, 150 CO-DE lncRNAs, and 13 CO-DE circRNAs identified during embryonic stages. Gene Ontology (GO) enrichment analysis unveiled associations primarily related to lens development, DNA conformational changes, and angiogenesis among DE mRNAs and lncRNAs. Furthermore, employing protein–protein interaction networks, mRNA–lncRNA co-expression networks, and circRNA–microRNA–mRNA networks, we predicted candidate key molecules implicated in lens development. Our findings underscore the pivotal roles of lncRNAs and circRNAs in this process, offering fresh insights into the pathogenesis of lens-related disorders and paving the way for future exploration in this field.

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Section: Discussionmentioning

confidence: 99%

Integrative transcriptomic profiling of ncRNAs and mRNAs in developing mouse lens

Zhang,

Liu,

et al. 2024

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…Deletion of VEGFA can lead to reduced vascular membrane production, resulting in smaller lenses with mild nuclear turbidity after birth, while overexpression can lead to excessive capillary formation and endothelial cell proliferation and deposition (Ash and Overbeek, 2000;Mitchell et al, 2006;Garcia et al, 2009). Ocular ischemia or inflammation may lead to the entry of VEGF into the lens capsule, resulting in the formation of new blood vessels (Roy et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Table6.XLSX

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“…Deletion of VEGFA can lead to reduced vascular membrane production, resulting in smaller lenses with mild nuclear turbidity after birth, while overexpression can lead to excessive capillary formation and endothelial cell proliferation and deposition (Ash and Overbeek, 2000;Mitchell et al, 2006;Garcia et al, 2009). Ocular ischemia or inflammation may lead to the entry of VEGF into the lens capsule, resulting in the formation of new blood vessels (Roy et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Table12.XLSX

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The red lens: a case of florid lens neovascularisation

Cited by 8 publications

References 5 publications

Integrative transcriptomic profiling of ncRNAs and mRNAs in developing mouse lens

Integrative transcriptomic profiling of ncRNAs and mRNAs in developing mouse lens

Table6.XLSX

Table12.XLSX

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