The reduction impact of monoglucosyl rutin on abdominal visceral fat: A randomized, placebo‐controlled, double‐blind, parallel‐group

Abstract

Water soluble α-glycosylated rutin (4G-α-D-glucopyranosyl rutin, monoglucosyl rutin, MR) was used in this study to evaluate its ability to reduce abdominal visceral fat (AVF). We conducted a study examining 66 healthy Japanese men and women with a body mass index of ≥23 and <30 kg/m 2 for 8 weeks. The subjects were randomly assigned to groups via computer random numbers as follows: MR200 group (MR 200 mg/day), MR400 group (MR 400mg/day), or placebo group. The primary outcome was change in the AVF area after 8 weeks of intervention. The secondary outcomes were effects of MR on total fat and subcutaneous fat of umbilical area, lipid-related markers, and subjective symptoms. The per-protocol set analysis involved 18 subjects in the placebo group (7 males and 11 females), 20 subjects in the MR200 group (8 males and 12 females), and 20 subjects in the MR400 group (8 males and 12 females). AVF area in both the MR200 and MR400 groups was reduced at week 8, with changes from the baseline (week 0) significantly higher than the placebo group. Additionally, the MR400 group reported improved subjective symptoms concerning being "worried about abdominal fat" at week 4 compared with the placebo group. These results indicate that the consumption of MR (200 and 400 mg/day) for 8 weeks reduced AVF.

Rutin targets AKT to inhibit ferroptosis in ventilator‐induced lung injury

“…In addition, there were no significant differences in lung tissues between the rutin group and the control group. Rutin is one of the most common native flavonoids (Bazyar et al, 2023; Corsale et al, 2018; Hashizume & Tandia, 2020). More and more clinical research has got insight into rutin and flavonoid mixture (Bazyar et al, 2023; Corsale et al, 2018; Hashizume & Tandia, 2020).…”

“…Rutin is one of the most common native flavonoids (Bazyar et al, 2023; Corsale et al, 2018; Hashizume & Tandia, 2020). More and more clinical research has got insight into rutin and flavonoid mixture (Bazyar et al, 2023; Corsale et al, 2018; Hashizume & Tandia, 2020). For example, daily oral supplementation of 500 mg of rutin may have beneficial effects on improving metabolic parameters in T2DM patients (Bazyar et al, 2023).…”

“…For example, daily oral supplementation of 500 mg of rutin may have beneficial effects on improving metabolic parameters in T2DM patients (Bazyar et al, 2023). Daily oral supplementation of 400 mg of monoglucosyl rutin may improve overall health by reducing abdominal visceral fat (Hashizume & Tandia, 2020). Daily oral supplementation of 1000 mg flavonoid mixture including 250 mg rutin reduced hemorrhoid bleeding and minimal adverse events were reported (Corsale et al, 2018).…”

Investigating the Anti-inflammatory Effects of Rutin in Carbon Tetrachloride-induced Hepatotoxicity: Role of TLR4/MyD88/NFκB Signaling Pathway Modulation

“…The combination of Rutin and vitamin C also strengthened the effects of blood glucose control, insulin resistance, lipid status, and oxidative stress markers in type 2 diabetes patients (Ragheb et al, 2020). In addition, the enzyme-modified form of Rutin, water-soluble α-glycosylated Rutin, can be applied to obese individuals to improve overall health by reducing abdominal visceral fat (Hashizume & Tandia, 2020). These all provide a reference value for the clinical application of Rutin, and in future clinical research on the treatment of liver diseases with Rutin, the following methods can also be used, but not limited to: (1) adding traditional drug compatibility, (2) combining with clinical medication, and (3) preparing new Rutin formulations.…”

Bioactive Compounds in Health and Disease – Focus on Rutin

“…In Compelling evidence indicates that foods rich in flavonoids are healthy [11,12]. Rutin, in particular, can really be considered a promising bioactive component of many functional foods [13]. Based on clinical evidence, it may have beneficial effects on the improvement of metabolic parameters, in particular glycaemia, as well as reducing their side effects [4,14]; ii) reduce hyperglycemia (%HbA1c) in combination with the antidiabetic drugs acarbose and canagliflozin [15]; iii) improve diabetic neuropathy by potentiating the antiinflammatory drug nimesulide [16]; and iv) manage osteoarthritis symptoms in combination with oral proteolytic enzymes [17].…”