The Reduction of Nitroarenes with Iron/Acetic Acid

“…The direct conversion of nitroaromatics into acetanilides has been reported in the literature under homogeneous conditions, [84] with iron powder and acetic acid [85] or molybdenumhexacarbonyl/acetic acid. The direct conversion of nitroaromatics into acetanilides has been reported in the literature under homogeneous conditions, [84] with iron powder and acetic acid [85] or molybdenumhexacarbonyl/acetic acid.…”

Section: Synthesis Of N-acyl-and N-(tert-butoxycarbonyl)amines: One-pmentioning

confidence: 99%

Heterogeneous Bifunctional Metal/Acid Catalysts for Selective Chemical Processes

et al. 2012

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Heterogeneous catalysts enabling multiple reaction sequences in one pot have a great potential for large‐scale production processes in terms of productivity, cost‐effectiveness, and low environmental impact. This paper reviews the most representative examples and the recent achievements in the field of solid bifunctional metal/acid‐site catalysts and their application to the production of fine chemicals through selective, cooperative, or sequential processes in single reactor units. The literature that appeared from January 2009 to January 2012 is covered.

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“…By a one‐pot approach and via a direct reductive‐acetylation of nitro compounds to acetamides, the mentioned drawbacks can be overcome. A literature review shows that some reducing and acetylating agents have been used for direct reductive‐acetylation of nitro compounds to acetamides . Although most of the reported methods have their own merits, however, they generally suffer from disadvantages in terms of the prolonged reaction times, tedious workup procedure, unsatisfactory yield, high temperature and use of the expensive and unrecoverable catalysts.…”

Section: Introductionmentioning

confidence: 99%

The immobilized Ni(II)‐thiourea complex on silica‐layered copper ferrite: A novel and reusable nanocatalyst for one‐pot reductive‐acetylation of nitroarenes

Zeynizadeh

Shokri

Galehban

2019

Applied Organom Chemis

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In this study, magnetically nanoparticles of CuFe2O4@SiO2@PTMS@Tu@Ni(II) as novel and reusable catalyst were prepared. Synthesis of the Ni (II)‐nanocatalyst was carried out through the complexation of Ni(OAc)2·4H2O with the immobilized thiourea on silica‐layered CuFe2O4. The prepared nanocomposite system was then characterized using SEM, EDX, XRD, VSM, ICP‐OES, Raman, UV–Vis and FT‐IR analyses. Catalytic activity of the Ni(II)‐CuFe2O4 system was investigated towards rapid reduction of aromatic nitro compounds to arylamines with sodium borohydride as well as one‐pot reductive‐acetylation of nitroarenes to acetanilides with NaBH4/Ac2O system without the isolation of intermediate arylamines. All reactions were carried out in H2O within 3–7 min to afford the products arylamines/acetanilides in high to excellent yields. Reusability of the Ni(II)‐nanocatalyst was examined for seven consecutive cycles without the significant loss of the catalytic activity.

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The Reduction of Nitroarenes with Iron/Acetic Acid

Cited by 59 publications

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A Novel Method for Synthesis of Flutamide on the Bench-Scale

A Novel Method for Synthesis of Flutamide on the Bench-Scale

Heterogeneous Bifunctional Metal/Acid Catalysts for Selective Chemical Processes

The immobilized Ni(II)‐thiourea complex on silica‐layered copper ferrite: A novel and reusable nanocatalyst for one‐pot reductive‐acetylation of nitroarenes

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