First, clarify the basic concepts of ERP system and axiomatic design, ERP system is the system to combine the needs of customers, the management and business activities of the enterprise itself and vendor information together, axiomatic design has two axioms including independent axiom and information axiom; then in order to achieve effective management of the entire supply chain, use independent axiom of axiomatic design to design the ERP system in the function, and reduce design complexity, companies can fully rely on ERP system to manage enterprise, play the characteristics of ERP system in the strategic decision-making, and improve their core competitiveness.