The Reflush Effect—a Prospective Analysis of Late Perfusion

Jp, Lodge; Sh, Kashi; Ft, Lam; A, Lord; Gr, Giles

doi:10.1097/00007890-199303000-00021

Cited by 10 publications

(3 citation statements)

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“…Although originally used to assess functional aerobic impairment in cardiovascular disease [66], the Bruce treadmill protocol has also been used in patients with CF and a variety of other pulmonary diseases such as COPD [70,71], pulmonary artery hypertension [72] and lung transplantation [73,74]. …”

Section: Routine Monitoring and Evaluation Of Exercise-related Symptomsmentioning

confidence: 99%

Statement on Exercise Testing in Cystic Fibrosis

Hebestreit

Arets²,

Aurora³

et al. 2015

Respiration

140

227

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This statement summarizes the information available on specific exercise test protocols and outcome parameters used in patients with cystic fibrosis (CF) and provides expert consensus recommendations for protocol and performance of exercise tests and basic interpretation of results for clinicians. The conclusions were reached employing consensus meetings and a wide-band Delphi process. Although data on utility are currently limited, standardized exercise testing provides detailed information on physiological health, allows screening for exercise-related adverse reactions and enables exercise counselling. The Godfrey Cycle Ergometer Protocol with monitoring of oxygen saturation and ventilatory gas exchange is recommended for exercise testing in people 10 years and older. Cycle ergometry only with pulse oximetry using the Godfrey protocol or treadmill exercise with pulse oximetry - preferably with measurement of gas exchange - are second best options. Peak oxygen uptake, if assessed, and maximal work rate should be reported as the primary measure of exercise capacity. The final statement was reviewed by the European Cystic Fibrosis society and revised based on the comments received. The document was endorsed by the European Respiratory Society.

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Section: Routine Monitoring and Evaluation Of Exercise-related Symptomsmentioning

confidence: 99%

Statement on Exercise Testing in Cystic Fibrosis

Hebestreit

Arets²,

Aurora³

et al. 2015

Respiration

140

227

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“…AA, is removed in dialysis [26, 321 before surgery. The technique of a re-flush (without AA) has been used earlier, achieving a reduction in postoperative dialysis requirement [16]. However, an increased incidence of rejection and some controversial histological changes have also been described [27].…”

Section: Discussionmentioning

confidence: 99%

Ascorbic acid against reperfusion injury in human renal transplantation

et al. 2003

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The cadaveric renal graft is exposed to ischaemic injury during preservation and to oxidative damage during reperfusion. Both these mechanisms are known to cause cell damage, which may impair graft function. Reperfusion injury (RPI) is mediated by reactive oxygen species (ROS). Ascorbic acid (AA) is a potent physiological extracellular scavenger of ROS. We perfused 31 renal grafts immediately before implantation with a solution of Euro-Collins containing 0.5 mg/ml of AA to diminish RPI. From every donor, the contralateral kidney served as a control. The control grafts were perfused with the same perfusion as those of the AA group, only without the AA substitution. We assessed the effect of AA by recording serum creatinine, creatinine clearance, initial graft function and early rejections. The incidence of delayed graft function (DGF) was 32% in the AA group, and 29% in the control group. Other parameters were also similar in both groups, except for the length of DGF, which showed a trend towards a shorter duration in the AA group. The pre-operative systemic AA concentration was significantly (P = 0.01) lower in the haemodialysis patients than in those on peritoneal dialysis. In conclusion, this clinical study could not demonstrate significant benefits of AA in renal transplantation.

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“…The preimplantation "rinse" is therefore particularly crucial for larger organs like the liver. Clinical practice differs with some centres using either a further dose of low potassium preservation solution [126], saline and albumin [127], or a specialised solution: Lemasters's "Carolina Rinse" solution being the mostly widely trialled in hepatic transplantation [128]. As an aid to preservation the "rinse" also clears the microcirculation of debris, replenishes anti-oxidants and provides further substrates for energy regeneration at reperfusion.…”

Section: Rinse Solutionsmentioning

confidence: 99%