2011
DOI: 10.1088/0031-9155/56/13/017
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The refractive index of human hemoglobin in the visible range

Abstract: Because the refractive index of hemoglobin in the visible range is sensitive to the hemoglobin concentration, optical investigations of hemoglobin are important for medical diagnostics and treatment. Direct measurements of the refractive index are, however, challenging; few such measurements have previously been reported, especially in a wide wavelength range. We directly measured the refractive index of human deoxygenated and oxygenated hemoglobin for nine wavelengths between 400 and 700 nm for the hemoglobin… Show more

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Cited by 179 publications
(137 citation statements)
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“…The refractive index of water (1.33) was used to scale OCT images to real distances. 16 All the measurements were performed at the room temperature of 22 AE 1°C.…”
Section: Methodsmentioning
confidence: 99%
“…The refractive index of water (1.33) was used to scale OCT images to real distances. 16 All the measurements were performed at the room temperature of 22 AE 1°C.…”
Section: Methodsmentioning
confidence: 99%
“…Since the index of refraction of hemoglobin may change from patient to patient [12,13,14], we accounted for the refractive index change according to the mean cell hemoglobin concentration that was measured independently by lysing the cells for each patient. Thus, the index of refractive depends linearly on the hemoglobin concentration of red blood cells as n c~b Czn w , where b is the refractive increment, C the hemoglobin concentration of the cell, and n w is the refractive index of water.…”
Section: Blood Sample Preparationmentioning
confidence: 99%
“…The second method as expressed by Eq. (2) is based on a long held and reasonably validated view assuming a linear relation for a type of biomolecules between its density and specific contribution to RI beyond n w [26][27][28][29]. Once RI values assigned to all voxels, an OCM was obtained and its morphology and/or RI can be modified to generate a series of OCMs derived from the same cell imaged by a confocal microscope.…”
Section: Establishment Of Ocm and Simulation Of Light Scatteringmentioning
confidence: 99%