The Refractory Glaucoma Surgery – The Indications, Complications, Outcomes

Fabrikantov, O.L.; Nikolashin, S.I.; Pirogova, E.S.

doi:10.20310/1810-0198-2016-21-1-204-207

“…Попытки применения цитостатиков для пролонгирования гипотензивного эффекта, снижения рубцевания и послеоперационных осложнений не оправдали всеобщих надежд и в свою очередь сопровождались такими тяжёлыми ослож нениями, как образование тонкостенной капсулы, формирование кистозной фильтрационной подушки, быстрое снижение гипотензивного эффекта [8,11].…”

Section: обзоры / Reviewsunclassified

Cyclodestructive interventions in refractory glaucoma treatment: history, reality, perspectives

Sokolovskaya

¹

,

Викторовна²,

Tikhonova

³

et al. 2019

Ophthalmology Reports

3

0

View full text Add to dashboard Cite

This article presents a historical evolution review of cyclodestructive methods in glaucoma treatment. It also provides the analysis of mechanism of action for each technology, their advantages and disadvantages. Results of clinical studies and most frequent complications of cyclodestructive procedures are also presented. The main attention is paid to the new MicroPulse laser technology, which is used for the treatment of primary open-angle glaucoma at various stages in patients with high visual acuity, as well as refractory forms of glaucoma. Data of clinical and experimental morphological studies of various modifications of transscleral cyclophotocoagulation technology are specified. Theories, research hypothesis upon the mechanism of MicroPulse laser action. In most researchers opinion, despite the relatively short observation period (from 6 months to 5 years), MicroPulse technology is recognized as effective and advanced.

show abstract

Pathomorphological features of conjunctival and scleral regeneration associated with intraoperative application of Cyclosporin A

Zhigalskaya

¹

,

Krivosheina

²

,

Dzyuman

³

et al. 2019

Bûll. sib. med.

0

View full text Add to dashboard Cite

Purpose. In experiment in vivo to study the features of regeneration of the conjunctiva and sclera of rats after surgery with intraoperative application of a 0.05% Ciclosporin A.Materials and methods. Еxperimental animals (rats) (n = 48) were divided into the main group, including the subgroups a (n = 16) and b (n = 16) and the comparison group (n = 16). Performed a through cut of the conjunctiva and damage to the surface layers of the sclera one of the eyes of all animals. Further on the surgical trauma zone in the main group, the intraoperative application of the cytostatic was performed. In the subgroup a with a duration of 3 minutes, in the subgroup b – 6 minutes. In the comparison group a hemostatic sponge without a cytostatic was used intraoperatively.Results. In the comparison group postoperative period proceeds with a stereotyped dynamics of cell phase changes in damaged tissues. In the end the development of dense conjunctival-scleral fusion in the area of surgical trauma was noted. Intraoperative application of 0.05% Cyclosporine A leads to a slowing of regeneration, preventing formation of rough conjunctival-scleral scar.Conclusions. Intraoperative applications of 0.05% Cyclosporin A change the stereotyped dynamics of the inflammatory-reparative regeneration in the surgical intervention zone, inhibiting the migration of cells almost in 3 times and significantly (in 2 times) prolonging the duration of the macrophage phase. This causes a slowdown of reparative regeneration, prevents excessive scarring in the operating area.

show abstract

Pathomorphological features of conjunctival and scleral regeneration associated with intraoperative application of Cyclosporin A

Zhigalskaya

¹

,

Krivosheina

²

,

Dzyuman

³

et al. 2019

Bûll. sib. med.

0

View full text Add to dashboard Cite

Purpose. In experiment in vivo to study the features of regeneration of the conjunctiva and sclera of rats after surgery with intraoperative application of a 0.05% Ciclosporin A.Materials and methods. Еxperimental animals (rats) (n = 48) were divided into the main group, including the subgroups a (n = 16) and b (n = 16) and the comparison group (n = 16). Performed a through cut of the conjunctiva and damage to the surface layers of the sclera one of the eyes of all animals. Further on the surgical trauma zone in the main group, the intraoperative application of the cytostatic was performed. In the subgroup a with a duration of 3 minutes, in the subgroup b – 6 minutes. In the comparison group a hemostatic sponge without a cytostatic was used intraoperatively.Results. In the comparison group postoperative period proceeds with a stereotyped dynamics of cell phase changes in damaged tissues. In the end the development of dense conjunctival-scleral fusion in the area of surgical trauma was noted. Intraoperative application of 0.05% Cyclosporine A leads to a slowing of regeneration, preventing formation of rough conjunctival-scleral scar.Conclusions. Intraoperative applications of 0.05% Cyclosporin A change the stereotyped dynamics of the inflammatory-reparative regeneration in the surgical intervention zone, inhibiting the migration of cells almost in 3 times and significantly (in 2 times) prolonging the duration of the macrophage phase. This causes a slowdown of reparative regeneration, prevents excessive scarring in the operating area.

show abstract

The Refractory Glaucoma Surgery – The Indications, Complications, Outcomes

Cited by 4 publications

References 0 publications

Cyclodestructive interventions in refractory glaucoma treatment: history, reality, perspectives

Cyclodestructive interventions in refractory glaucoma treatment: history, reality, perspectives

Pathomorphological features of conjunctival and scleral regeneration associated with intraoperative application of Cyclosporin A

Pathomorphological features of conjunctival and scleral regeneration associated with intraoperative application of Cyclosporin A

Contact Info

Product

Resources

About