The Regional Burden and Disability-Adjusted Life Years of Knee Osteoarthritis in Kazakhstan 2014–2020

Abstract

A Global Burden of Disease (GBD) study reported that 9.6 million years lived with disability (YLDs) were lost due to hip and knee osteoarthritis (KOA) in 2017. Although the GBD study presents the disease burden at the global level, there is no information on any Central Asian country. This study aims to investigate the epidemiology of knee osteoarthritis in Kazakhstan. The data of 56,895 people with KOA between 2014–2020 was derived from the Unified National Electronic Health System of Kazakhstan and retrospectively analyzed. The majority of the cohort (76%) were women, of Kazakh ethnicity (66%), and older than 50 years of age (87%). The risk of gonarthrosis escalated for women after 50 years and peaked at 75 years with a rate of 3062 females admitted to hospital per 100,000 women in the population. This observation is approximately three times higher than for men of the same age group. A geographical analysis showed that the Jambyl oblast, West Kazakhstan, North Kazakhstan, and the Akmola oblast have the highest burden of disease. During the observation period, 127,077 age-adjusted YLDs were lost due to knee osteoarthritis. This is the first study in Kazakhstan to investigate the burden of knee osteoarthritis. This research recognizes age and sex-based differences, and regional disparities in the incidence of knee osteoarthritis. This knowledge can lead to the development of more specific diagnostic approaches and gender-personalized therapy protocols for patients.

Burden of osteoarthritis in China, 1990–2019: findings from the Global Burden of Disease Study 2019

“…The higher the level of economic development, the higher the disease burden of osteoarthritis. Similar results were also reported in previous studies [ 20 , 21 ], and an increasing life expectancy is a non-negligible explanation for this result. In 2019, the number of cases and incidence rate of osteoarthritis in China was 10,681,311 and 750.96/100,000, respectively.…”

A Study on the Rehabilitation of Patients with Osteoarthritis of the Knee

“…Structural changes in the organism for the joint area can cause physical pain, limb dysfunction, the development of psychiatric disorders, and a variety of chronic diseases, which can seriously affect the patient's quality of life. At the same time, there are other risk factors for osteoarthritis of the knee, such as: overweight or obesity, post-sport injuries of the knee, muscle weakness of the lower limbs, knee osteoarthritis, etc [5][6]. The prevalence of osteoarthritis of the knee in the Chinese population is 8.1%, and there is a significant gender difference: women suffer perhaps a heavier burden of disease than men [7].…”

“…In summary, in recent years, with the aging of China's population rising year by year, the incidence of osteoarthritis of the knee is also on the rise [5], and there is an urgent need for effective clinical as well as rehabilitation treatment measures [60]. In recent years, the prevalence of osteoarthritis of the knee in young adults has also been on the rise, and the increasing incidence and prevalence will bring a heavy burden to the world health system [62].…”

Global burden and socioeconomic impact of knee osteoarthritis: a comprehensive analysis

“…By analyzing the GBD database, Safiri et al ( 9 ) reported the global, regional and national burden of osteoarthritis. Zhakhina et al ( 10 ) reported the disease burden of KOA in Kazakhstan. Similarly, Hoveidaei et al ( 11 ) reported the disease burden of KOA in the Middle East, and Song et al ( 12 ) reported the disease burden of KOA in China.…”