The regional hypothalamic distribution of type II 5′-monodeiodinase in euthyroid and hypothyroid rats

Riskind, Peter; Kolodny, J. M.; Larsen, P. Reed

doi:10.1016/0006-8993(87)90260-5

Cited by 84 publications

(42 citation statements)

References 15 publications

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“…This establish a role for T3(T4) in TRH regulation as well. The origin of the T3(T4) which regulates TRH synthesis in the PVN is not certain since there is no D2 present in that location (16). The accepted hypothesis is that it originates from D2-containing tanycytes in inferior portions of the third ventricle-the mediobasal hypothalamus (MBH) (16,17).…”

Section: Deiodinases In Thyroid Physiologymentioning

confidence: 99%

Physiological role and regulation of iodothyronine deiodinases: A 2011 update

Marsili

Zavacki

Harney

et al. 2011

J Endocrinol Invest

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Thyroxine (T4) is a prohormone secreted by the thyroid. T4 has a long half life in circulation and it is tightly regulated to remain constant in a variety of circumstances. However, the availability of iodothyronine selenodeiodinases allow both the initiation or the cessation of thyroid hormone action and can result in surprisingly acute changes in the intracellular concentration of the active hormone T3, in a tissue-specific and chronologically-determined fashion, in spite of the constant circulating levels of the prohormone. This fine-tuning of thyroid hormone signaling is becoming widely appreciated in the context of situations where the rapid modifications in intracellular T3 concentrations are necessary for developmental changes or tissue repair. Given the increasing availability of genetic models of deiodinase deficiency, new insights into the role of these important enzymes are being recognized. In this review, we have incorporated new information regarding the special role played by these enzymes into our current knowledge of thyroid physiology, emphasizing the clinical significance of these new insights.

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Section: Deiodinases In Thyroid Physiologymentioning

confidence: 99%

Physiological role and regulation of iodothyronine deiodinases: A 2011 update

Marsili

Zavacki

Harney

et al. 2011

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

“…Brain cells are especially sensitive to thyroid hormone activity, which is manifested by maintaining their own thyroid hormone homeostasis, different from that present in other organs [28,29]. Type 2 and 3 iodothyronine deiodinases play an important role in the formation of this homeostasis.…”

Section: Transport Of Thyroid Hormone From Circulation To the Brainmentioning

confidence: 99%

“…Type 2 and 3 iodothyronine deiodinases play an important role in the formation of this homeostasis. Monodeiodination of thyroxine to triiodothyronine catalysed by D-2 occurs mainly in specialised glial cells named tanycytes, located in the hypothalamus, and in astrocytes, present in the entire brain [28][29][30]. In the brains of adult rats about 80% of T3 that is bound to specific nuclear receptors of thyroid hormones (THRs) is produced locally in the course of monodeiodination of T4 to T3 [29].…”

Section: Transport Of Thyroid Hormone From Circulation To the Brainmentioning

confidence: 99%

“…Komórki mózgu można zaliczyć do szczególnie wrażli-wych na działanie hormonów tarczycy, co manifestuje się między innymi utrzymywaniem własnej, odmiennej od innych narządów homeostazy hormonów tarczycy [28,29]. Istotną rolę w tworzeniu tej homeostazy odgrywają jodotyroninowe dejodynazy typu 2 i 3.…”

Section: Homeostaza Hormonów Tarczycy W Mózgu I Jej Zaburzenia W Guzaunclassified

“…Istotną rolę w tworzeniu tej homeostazy odgrywają jodotyroninowe dejodynazy typu 2 i 3. Głównymi komórkami mózgu, w których ma miejsce monodejodynacja tyroksyny do trijodotyroniny są zlokalizowane głównie w podwzgórzu w komórkach gleju -tanocyty i znajdujące się w całym mózgu astrocyty [28][29][30]. Znacząca część transportowanej do tanocytów i astrocytów tyroksyny jest odjodowywana do trijodotyroniny.…”

Section: Homeostaza Hormonów Tarczycy W Mózgu I Jej Zaburzenia W Guzaunclassified

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The regional hypothalamic distribution of type II 5′-monodeiodinase in euthyroid and hypothyroid rats

Cited by 84 publications

References 15 publications

Physiological role and regulation of iodothyronine deiodinases: A 2011 update

Physiological role and regulation of iodothyronine deiodinases: A 2011 update

Hormony tarczycy w ośrodkowym układzie nerwowym (OUN) i ich wpływ na nowotworzenie, zwłaszcza na rozwój i przebieg glioblastoma multiforme — hipoteza badawcza

Feedback Regulation of Thyrotropin‐Releasing Hormone Gene Expression by Thyroid Hormone in the Hypothalamic Paraventricular Nucleus

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