In recent years, China’s regional economic differences have become more and more apparent, and the problem of unbalanced allocation of financial resources has become more and more prominent. In this context, it is of great practical significance to study the construction strategy of regional investment and financial management systems using the spatial effect model. This study adopts the spatial econometric method to establish the spatial effect model. Considering the limitations of the spatial panel data model, this paper also uses the general dynamic spatial panel model with fixed effects to analyze the relationship between regional investment and the financial management system. Finally, through the Granger causality test on the spatial effect analysis of regional investment and financial management, this paper verifies the study of the interaction between the financial management system and regional investment. The research data show that in the spatial panel model, the regression coefficient of the explanatory variable F financial management system is 0.2431, which is significant at the 1% level, indicating that with a little increase in the degree of financial management system, the regional economy grows by 0.2431. The fixed effect general dynamic spatial panel model’s superiority is confirmed by the higher goodness of fit of the general dynamic spatial panel model compared to the spatial panel model.