The regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy

Jiang, Xin; Yu, Min; Wang, Wei-kai; Zhu, Li-yuan; Wang, Xian; Jin, Hong-chuan; Feng, Li-feng

doi:10.1038/s41401-024-01336-2

Acta Pharmacol Sin

2024

DOI: 10.1038/s41401-024-01336-2

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The regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy

Xin Jiang,

Min Yu,

Wei-kai Wang

et al.

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Cited by 4 publications

References 132 publications

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Ferroptosis in hepatocellular carcinoma: Mechanisms and therapeutic implications

Tu,

Zou,

Yang

et al. 2025

Biomedicine & Pharmacotherapy

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Ferroptosis in hepatocellular carcinoma: Mechanisms and therapeutic implications

Tu,

Zou,

Yang

et al. 2025

Biomedicine & Pharmacotherapy

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Nrf2 inhibition and NCOA4-mediated ferritinophagy activation synergistically exacerbated S-3′-hydroxy-7′, 2′, 4′-trimethoxyisoxane induced ferroptosis in lung cancer cells

Liu,

Zhou,

Chen

et al. 2025

Chemico-Biological Interactions

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Decoding ferroptosis: transforming orthopedic disease management

Huo,

Lin,

Liu

et al. 2024

Front. Pharmacol.

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As a mechanism of cell death, ferroptosis has gained popularity since 2012. The process is distinguished by iron toxicity and phospholipid accumulation, in contrast to autophagy, apoptosis, and other cell death mechanisms. It is implicated in the advancement of multiple diseases across the body. Researchers currently know that osteosarcoma, osteoporosis, and other orthopedic disorders are caused by NRF2, GPX4, and other ferroptosis star proteins. The effective relief of osteoarthritis symptoms from deterioration has been confirmed by clinical treatment with multiple ferroptosis inhibitors. At the same time, it should be reminded that the mechanisms involved in ferroptosis that regulate orthopedic diseases are not currently understood. In this manuscript, we present the discovery process of ferroptosis, the mechanisms involved in ferroptosis, and the role of ferroptosis in a variety of orthopedic diseases. We expect that this manuscript can provide a new perspective on clinical diagnosis and treatment of related diseases.

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The regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy

Cited by 4 publications

References 132 publications

Ferroptosis in hepatocellular carcinoma: Mechanisms and therapeutic implications

Ferroptosis in hepatocellular carcinoma: Mechanisms and therapeutic implications

Nrf2 inhibition and NCOA4-mediated ferritinophagy activation synergistically exacerbated S-3′-hydroxy-7′, 2′, 4′-trimethoxyisoxane induced ferroptosis in lung cancer cells

Decoding ferroptosis: transforming orthopedic disease management

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